- The objective of this study was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for obesity and diabetes. Our aim was to determine the relationship between vitamin D3 and metabolic syndrome, and investigate the effect of vitamin D3 supplementation on hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity. We conducted a study between January 2018 and January 2020, with a total of 723 children invited to participate. Of these, 283 were in the vitamin D supplement group (SG) and 440 were in the placebo group (PG). We evaluated blood pressure, fasting glucose, high-density lipoprotein, total cholesterol, low-density lipoprotein, and bone mineral density (BMD) in all subjects. We observed that cholesterol, triglyceride, and glucose levels were strongly associated with 25(OH)D3 levels at baseline. After vitamin D3 supplementation, we observed a significant increase in body mass index (BMI) (P = 0.02) and serum 25(OH)D3 (P < 0.01) levels in the vitamin D3 group compared to the placebo group. Additionally, serum lipids such as total cholesterol (P <0.01), HDL-c (P < 0.01), total cholesterol/HDL-c (P < 0.01), LDL-c/HDL-c (P < 0.01), and triglycerides/HDL-c (P < 0.01) were significantly decreased in the vitamin D group compared to the placebo group. Serum vitamin D3 was inversely associated with cholesterol, triglycerides, and fasting glucose. Our results suggest that vitamin D3 supplementation enhances the beneficial effect of hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity. |
- The aim of this study was to describe the childhood experiences of polio patients after the isolation phase of the disease in post-war Finland in the 1950s and 1960s. Qualitative empirical research was conducted. Interview material was gathered through theme-based written interviews, and the data were analyzed using reflective thematic analysis. The analysis resulted in the overarching main theme of "constructing psychological safety," which reflected the themes "emotionally inadequate care," "reclaiming physical identity," and "the need to construct a child's world." These themes and their subthemes highlighted children's experiences of the rules set by adults as well as their subordinate relationships with adults. Polio survivors' experiences following the isolation phase of the disease were traumatic and demonstrated children's inferior position in nursing in Finland in the 1950s and 1960s. Specifically, children recovering from polio experienced traumatic treatment and care and loneliness even beyond the isolation phase of the disease. |