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821596 occurrences (No.5 in the rank) during 5 years in the PubMed. [no cache] 500 found

286) Additionally, our results support that TA use in patients who underwent oSRP with osteotomies was found clinically and statistically effective for prevention of bleeding during oSRP operations and reduction of both periorbital edema and ecchymosis.

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PMID:24149401 DOI:10.1097/SAP.0b013e3182a1e527

2015 Annals of plastic surgery

* The efficacy of tranexamic acid and corticosteroid on edema and ecchymosis in septorhinoplasty.

- The aim of this study was to investigate the efficacy of tranexamic acid (TA) and methylprednisolone on periorbital edema, ecchymosis, and intraoperative bleeding in patients who underwent open septorhinoplasty (oSRP). Seventy-five patients performing hump extraction and osteotomies were allocated into 3 groups as follows: group 1, 25 patients as control; group 2, 25 patients who were administered oral TA as first dose 1 g starting 2 hours before surgery, 3 g daily in divided doses (1 g, every 8 hours) for 5 days; and group 3, 25 patients who were administered a single dose of 1 mg/kg intravenous methylprednisolone at the beginning of the surgery. Operation time, amount of intraoperative bleeding, and complications were recorded. Scoring of eyelid edema and periorbital ecchymosis was evaluated on postoperative first, third, and seventh days using scale of 0 to 4 by 2 observers. In groups using TA and methylprednisolone, periorbital edema and ecchymosis scores were significantly lower compared with the control group (P < 0.05). No significant difference was seen clinically and statistically in preventing or decreasing both periorbital edema and ecchymosis between group 2 and group 3. Patients given TA showed significantly less intraoperative bleeding compared with controls and patients who were administered methylprednisolone. We observed that the administration of methylprednisolone significantly decreases periorbital edema and ecchymosis. Additionally, our results support that TA use in patients who underwent oSRP with osteotomies was found clinically and statistically effective for prevention of bleeding during oSRP operations and reduction of both periorbital edema and ecchymosis.

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(1)263 of	(8)5 is	(15)3 by	(22)2 at
(2)34 in	(9)5 was	(16)3 it	(23)2 has
(3)24 null	(10)5 with	(17)3 these	(24)2 therapeutic
(4)24 and	(11)4 a	(18)3 were	(25)2 to
(5)8 the	(12)4 among	(19)3 when	(26)2 visual
(6)5 as	(13)3 are	(20)2 TAA
(7)5 for	(14)3 because	(21)2 acculturation,

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--- WordNet output for use --- =>利用, 使う, 利用する, (体, 能力など)を働かす, 使用, 利用法 Overview of noun use The noun use has 7 senses (first 6 from tagged texts) 1. (90) use, usage, utilization, utilisation, employment, exercise -- (the act of using; "he warned against the use of narcotic drugs"; "skilled in the utilization of computers") 2. (18) function, purpose, role, use -- (what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?") 3. (7) use -- (a particular service; "he put his knowledge to good use"; "patrons have their uses") 4. (1) consumption, economic consumption, usance, use, use of goods and services -- ((economics) the utilization of economic goods to satisfy needs or in manufacturing; "the consumption of energy has increased steadily") 5. (1) habit, use -- ((psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition; "owls have nocturnal habits"; "she had a habit twirling the ends of her hair"; "long use had hardened him to it") 6. (1) manipulation, use -- (exerting shrewd or devious influence especially for one's own advantage; "his manipulation of his friends was scandalous") 7. use, enjoyment -- ((law) the exercise of the legal right to enjoy the benefits of owning property; "we were given the use of his boat") Overview of verb use The verb use has 6 senses (first 3 from tagged texts) 1. (603) use, utilize, utilise, apply, employ -- (put into service; make work or employ for a particular purpose or for its inherent or natural purpose; "use your head!"; "we only use Spanish at home"; "I can't use this tool"; "Apply a magnetic field here"; "This thinking was applied to many projects"; "How do you utilize this tool?"; "I apply this rule to get good results"; "use the plastic bags to store the food"; "He doesn't know how to use a computer") 2. (12) use, habituate -- (take or consume (regularly or habitually); "She uses drugs rarely") 3. (8) use, expend -- (use up, consume fully; "The legislature expended its time on school questions") 4. use -- (seek or achieve an end by using to one's advantage; "She uses her influential friends to get jobs"; "The president's wife used her good connections") 5. practice, apply, use -- (avail oneself to; "apply a principle"; "practice a religion"; "use care when going down the stairs"; "use your common sense"; "practice non-violent resistance") 6. use -- (habitually do something (use only in the past tense); "She used to call her mother every week but now she calls only occasionally"; "I used to get sick when I ate in that dining hall"; "They used to vacation in the Bahamas") --- WordNet end ---