ELIZA

return kwic search for under out of >500 occurrences
321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [no cache] 500 found

290) The influence of compression force and speed during tablet manufacture under simulated rotary press production conditions were also evaluated.

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PMID:24354893 DOI:10.3109/10837450.2013.871035

2015 Pharmaceutical development and technology

* Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium.

- The preparation of lipophilic matrix tablets for the sustained release of water soluble drugs via direct compression is not always feasible due to poor flow and rapid drug release. The aim was to evaluate the potential for developing sustained-release diclofenac sodium tablets, using Compritol® 888 ATO as a lipid matrix, by a wet granulation technique. The effects of wet granulation method (planetary mixer and fluid-bed) and liquid binder type (HPMC Metolose® 603, 606 or 615) on weight uniformity, tensile strength and release rates were investigated. The influence of compression force and speed during tablet manufacture under simulated rotary press production conditions were also evaluated. Rapid release of diclofenac sodium from directly compressed matrices was observed. A wet granulation technique using different HPMC binders produced free-flowing granules and matrices which released diclofenac sodium in a sustained manner over several hours. When the formulation comprising the lowest viscosity grade HPMC (Metolose® 603) was further evaluated using a laboratory scale fluid-bed system, consistently sized granules with good flowability and matrices with good weight uniformity and tensile strengths were produced. Release rates were consistent over a range of compression speeds and forces indicating the suitability of the formulation for production on a rotary tablet press.

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(1)95 the	(18)4 these	(35)2 axial	(52)2 of
(2)13 different	(19)3 high	(36)2 censoring	(53)2 optimal
(3)12 a	(20)3 investigation	(37)2 clinical	(54)2 physiological
(4)9 general	(21)3 light	(38)2 consideration	(55)2 pulsatile
(5)8 both	(22)3 local	(39)2 controlled	(56)2 scanning
(6)8 which	(23)3 mechanical	(40)2 current	(57)2 serum-free
(7)7 various	(24)2 null	(41)2 evaluation	(58)2 several
(8)6 conditions	(25)2 12	(42)2 ex	(59)2 simulated
(9)6 curve	(26)2 15	(43)2 extreme	(60)2 specific
(10)6 static	(27)2 2	(44)2 four	(61)2 steady-state
(11)5 and	(28)2 CA	(45)2 hypertensive	(62)2 therapy
(12)4 5	(29)2 CT	(46)2 hypoxia	(63)2 this
(13)4 certain	(30)2 H2O2-induced	(47)2 hypoxic	(64)2 time
(14)4 control	(31)2 UV	(48)2 inflammatory	(65)2 treatment
(15)4 either	(32)2 acute	(49)2 laser	(66)2 ultrasound
(16)4 in	(33)2 additive	(50)2 lateral	(67)2 vertical
(17)4 normal	(34)2 adverse	(51)2 mortality	(68)2 water

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--- WordNet output for under --- =>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に Overview of adj under The adj under has 2 senses (first 2 from tagged texts) 1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under parts of a machine") 2. (1) under -- (lower in rank, power, or authority; "an under secretary") Overview of adv under The adv under has 8 senses (first 1 from tagged texts) 1. (2) under -- (down to defeat, death, or ruin; "their competitors went under") 2. under -- (through a range downward; "children six and under will be admitted free") 3. under -- (into unconsciousness; "this will put the patient under") 4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment under") 5. under -- (below some quantity or limit; "fifty dollars or under") 6. under -- (below the horizon; "the sun went under") 7. under -- (down below; "get under quickly!") 8. under, below -- (further down; "see under for further discussion") --- WordNet end ---