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321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [no cache]
500 found
254) Disulfiram, another small molecule currently under evaluation in clinical trials for reactivation of latent HIV-1, was also found capable of inducing CDK9 Thr-186 phosphorylation and Cyclin T1 levels in resting CD4(+) T cells from healthy donors.
* Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV.
- The histone deacetylase inhibitor (HDACi) suberoylanilide hydroxyamic acid (SAHA), also known as vorinostat, has recently been reported to activate latent HIV-1 in patients undergoing antiretroviral therapy. It is possible that SAHA reactivation of latent viruses may involve effects on cellular transcription factors such as positive transcription elongation factor b (P-TEFb), a protein kinase whose core is composed of CDK9 and Cyclin T1. P-TEFb is recruited by the HIV-1 Tat protein to activate productive RNA polymerase II elongation of the integrated provirus. We found that SAHA treatment of isolated resting CD4(+) T cells induced CDK9 Thr-186 (T-loop) phosphorylation in six of eight healthy donors and increased Cyclin T1 expression in one donor; Thr-186 phosphorylation is required for P-TEFb function. Disulfiram, another small molecule currently under evaluation in clinical trials for reactivation of latent HIV-1, was also found capable of inducing CDK9 Thr-186 phosphorylation and Cyclin T1 levels in resting CD4(+) T cells from healthy donors. In a Jurkat CD4(+) T cells HIV-1 latency system, disulfiram reactivated the latent provirus and induced CDK9 Thr-186 phosphorylation. Our findings suggest that small molecules capable of reactivating latent HIV-1 in resting CD4(+) T cells may function in part by increasing CDK9 Thr-186 phosphorylation and perhaps Cyclin T1 expression, thereby up-regulating P-TEFb function.
=>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に
Overview of adj under
The adj under has 2 senses (first 2 from tagged texts)
1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under
parts of a machine")
2. (1) under -- (lower in rank, power, or authority; "an under secretary")
Overview of adv under
The adv under has 8 senses (first 1 from tagged texts)
1. (2) under -- (down to defeat, death, or ruin; "their competitors went under")
2. under -- (through a range downward; "children six and under will be admitted free")
3. under -- (into unconsciousness; "this will put the patient under")
4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment
under")
5. under -- (below some quantity or limit; "fifty dollars or under")
6. under -- (below the horizon; "the sun went under")
7. under -- (down below; "get under quickly!")
8. under, below -- (further down; "see under for further discussion")
--- WordNet end ---