ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for under out of >500 occurrences
321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [no cache] 500 found
237) In all patients, the risk rs3130 TT variant genotype was significantly associated with overall survival (OS) (adjusted P(trend) = 0.016 and 0.007 under additive and recessive models, respectively).
--- ABSTRACT ---
PMID:24302553 DOI:10.1002/mc.22113
2015 Molecular carcinogenesis
* Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.
- CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk and patient survival. We hypothesized that potentially functional CD133 SNPs are associated with gastric cancer (GC) risk and survival. To test this hypothesis, we conducted a case-control study of 371 GC patients and 313 cancer-free controls frequency-matched by age, sex, and ethnicity. We genotyped four selected, potentially functional CD133 SNPs (rs2240688A>C, rs7686732C>G, rs10022537T>A, and rs3130C>T) and used logistic regression analysis for associations of these SNPs with GC risk and Cox hazards regression analysis for survival. We found that compared with the miRNA binding site rs2240688 AA genotype, AC + CC genotypes were associated with significantly increased GC risk (adjusted OR = 1.52, 95% CI = 1.09-2.13); for another miRNA binding site rs3130C>T SNP, the TT genotype was associated with significantly reduced GC risk (adjusted OR = 0.68, 95% CI = 0.48-0.97), compared with CC + CT genotypes. In all patients, the risk rs3130 TT variant genotype was significantly associated with overall survival (OS) (adjusted P(trend) = 0.016 and 0.007 under additive and recessive models, respectively). These findings suggest that these two CD133 miRNA binding site variants, rs2240688 and rs3130, may be potential biomarkers for genetic susceptibility to GC and possible predictors for survival in GC patients but require further validation by larger studies.
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(1)95 the (18)4 these (35)2 axial (52)2 of
(2)13 different (19)3 high (36)2 censoring (53)2 optimal
(3)12 a (20)3 investigation (37)2 clinical (54)2 physiological
(4)9 general (21)3 light (38)2 consideration (55)2 pulsatile
(5)8 both (22)3 local (39)2 controlled (56)2 scanning
(6)8 which (23)3 mechanical (40)2 current (57)2 serum-free
(7)7 various (24)2 *null* (41)2 evaluation (58)2 several
(8)6 conditions (25)2 12 (42)2 ex (59)2 simulated
(9)6 curve (26)2 15 (43)2 extreme (60)2 specific
(10)6 static (27)2 2 (44)2 four (61)2 steady-state
(11)5 and (28)2 CA (45)2 hypertensive (62)2 therapy
(12)4 5 (29)2 CT (46)2 hypoxia (63)2 this
(13)4 certain (30)2 H2O2-induced (47)2 hypoxic (64)2 time
(14)4 control (31)2 UV (48)2 inflammatory (65)2 treatment
(15)4 either (32)2 acute (49)2 laser (66)2 ultrasound
(16)4 in (33)2 additive (50)2 lateral (67)2 vertical
(17)4 normal (34)2 adverse (51)2 mortality (68)2 water

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--- WordNet output for under --- =>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に Overview of adj under The adj under has 2 senses (first 2 from tagged texts) 1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under parts of a machine") 2. (1) under -- (lower in rank, power, or authority; "an under secretary") Overview of adv under The adv under has 8 senses (first 1 from tagged texts) 1. (2) under -- (down to defeat, death, or ruin; "their competitors went under") 2. under -- (through a range downward; "children six and under will be admitted free") 3. under -- (into unconsciousness; "this will put the patient under") 4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment under") 5. under -- (below some quantity or limit; "fifty dollars or under") 6. under -- (below the horizon; "the sun went under") 7. under -- (down below; "get under quickly!") 8. under, below -- (further down; "see under for further discussion") --- WordNet end ---