ELIZA

return kwic search for under out of >500 occurrences
321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [cache]

189) Patients were scanned twice, under either an acute dose of Fluoxetine or placebo in a double-blind, placebo-controlled randomized design.

--- ABSTRACT ---

PMID:24451919 DOI:10.1093/cercor/bht365

2015 Cerebral cortex (New York, N.Y. : 1991)

* Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism.

- Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) share brain function abnormalities during cognitive flexibility. Serotonin is involved in both disorders, and selective serotonin reuptake inhibitors (SSRIs) can modulate cognitive flexibility and improve behavior in both disorders. Thus, this study investigates shared and disorder-specific brain dysfunctions in these 2 disorders during reward reversal, and the acute effects of an SSRI on these. Age-matched boys with ADHD (15), ASD (18), and controls (21) were compared with functional magnetic resonance imaging (fMRI) during a reversal task. Patients were scanned twice, under either an acute dose of Fluoxetine or placebo in a double-blind, placebo-controlled randomized design. Repeated-measures analyses within patients assessed drug effects. Patients under each drug condition were compared with controls to assess normalization effects. fMRI data showed that, under placebo, ASD boys underactivated medial prefrontal cortex (mPFC), compared with control and ADHD boys. Both patient groups shared decreased precuneus activation. Under Fluoxetine, mPFC activation was up-regulated and normalized in ASD boys relative to controls, but down-regulated in ADHD boys relative to placebo, which was concomitant with worse task performance in ADHD. Fluoxetine therefore has inverse effects on mPFC activation in ASD and ADHD during reversal learning, suggesting dissociated underlying serotonin abnormalities.

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(1)95 the	(18)4 these	(35)2 axial	(52)2 of
(2)13 different	(19)3 high	(36)2 censoring	(53)2 optimal
(3)12 a	(20)3 investigation	(37)2 clinical	(54)2 physiological
(4)9 general	(21)3 light	(38)2 consideration	(55)2 pulsatile
(5)8 both	(22)3 local	(39)2 controlled	(56)2 scanning
(6)8 which	(23)3 mechanical	(40)2 current	(57)2 serum-free
(7)7 various	(24)2 null	(41)2 evaluation	(58)2 several
(8)6 conditions	(25)2 12	(42)2 ex	(59)2 simulated
(9)6 curve	(26)2 15	(43)2 extreme	(60)2 specific
(10)6 static	(27)2 2	(44)2 four	(61)2 steady-state
(11)5 and	(28)2 CA	(45)2 hypertensive	(62)2 therapy
(12)4 5	(29)2 CT	(46)2 hypoxia	(63)2 this
(13)4 certain	(30)2 H2O2-induced	(47)2 hypoxic	(64)2 time
(14)4 control	(31)2 UV	(48)2 inflammatory	(65)2 treatment
(15)4 either	(32)2 acute	(49)2 laser	(66)2 ultrasound
(16)4 in	(33)2 additive	(50)2 lateral	(67)2 vertical
(17)4 normal	(34)2 adverse	(51)2 mortality	(68)2 water

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--- WordNet output for under --- =>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に Overview of adj under The adj under has 2 senses (first 2 from tagged texts) 1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under parts of a machine") 2. (1) under -- (lower in rank, power, or authority; "an under secretary") Overview of adv under The adv under has 8 senses (first 1 from tagged texts) 1. (2) under -- (down to defeat, death, or ruin; "their competitors went under") 2. under -- (through a range downward; "children six and under will be admitted free") 3. under -- (into unconsciousness; "this will put the patient under") 4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment under") 5. under -- (below some quantity or limit; "fifty dollars or under") 6. under -- (below the horizon; "the sun went under") 7. under -- (down below; "get under quickly!") 8. under, below -- (further down; "see under for further discussion") --- WordNet end ---