70) Recent evidence has shown that microRNAs (miRNAs) are involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC). |
PMID:24469061 DOI:10.1038/onc.2013.574 |
2015 Oncogene |
* MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway. |
- The metastatic cascade is a complex and multistep process with many potential barriers. Recent evidence has shown that microRNAs (miRNAs) are involved in carcinogenesis and tumor progression in non-small-cell lung cancer (NSCLC). In this study, by comparing the miRNA expression profiles of SPC-A-1sci (high metastatic) and SPC-A-1 (weakly metastatic) cells, we demonstrated that the downregulation and function of miR-193a-3p and miR-193a-5p in NSCLC metastasis and the expression of these miRNAs was suppressed in NSCLC compared with corresponding non-tumorous tissues. Decreased miR-193a-3p/5p expression was significantly associated with tumor node metastasis (TNM) and lymph node metastasis. Furthermore, functional assays showed that the overexpression of miR-193a-3p/5p inhibited NSCLC cell migration, invasion and epithelial-mesenchymal transition (EMT) in vitro and lung metastasis formation in vivo. In addition, we discovered that ERBB4 and S6K2 were the direct targets of miR-193a-3p and that PIK3R3 and mTOR were the direct targets of miR-193a-5p in NSCLC. We also observed that miR-193a-3p/5p could inactivate the AKT/mTOR signaling pathway. Thus, miR-193a-3p/5p functions as a tumor suppressor and has an important role in NSCLC metastasis through ERBB signaling pathway. |
(1)36 cells | (17)6 size | (33)3 lysis | (49)2 progression, |
(2)23 suppressor | (18)6 suppression | (34)3 onset | (50)2 recurred |
(3)22 progression | (19)6 tissue | (35)3 targeting | (51)2 recurrence |
(4)20 necrosis | (20)6 with | (36)3 to | (52)2 regression |
(5)19 *null* | (21)5 angiogenesis | (37)3 types | (53)2 response |
(6)17 growth | (22)5 initiating | (38)2 1 | (54)2 samples, |
(7)15 cell | (23)5 suppressive | (39)2 activity | (55)2 site |
(8)14 was | (24)5 volume | (40)2 burden | (56)2 size, |
(9)12 and | (25)4 model | (41)2 classification | (57)2 that |
(10)11 development | (26)4 sites | (42)2 composed | (58)2 the |
(11)11 in | (27)4 suppressors | (43)2 expression | (59)2 tissue, |
(12)11 of | (28)3 effects | (44)2 heterogeneity | (60)2 tissues |
(13)7 microenvironment | (29)3 excision | (45)2 invasion | (61)2 treatment |
(14)6 formation | (30)3 extension | (46)2 is | |
(15)6 promotion | (31)3 had | (47)2 metastasis | |
(16)6 samples | (32)3 local | (48)2 mice |
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