ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for tumor out of >500 occurrences
305909 occurrences (No.73 in the rank) during 5 years in the PubMed. [no cache] 500 found
29) Immunohistochemical staining, Western blot and reverse transcriptase quantitative (RT-qPCR) were used to determine GLUT-1 protein and mRNA expression of the tumor cells.
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PMID:24502553 DOI:10.7785/tcrt.2012.500412
2015 Technology in cancer research & treatment
* Silencing of Glucose Transporter Protein-1 by RNA Interference Inhibits Human Osteosarcoma Mg63 Cells Growth in vivo.
- While knock-down of glucose transporter protein 1 (GLUT-1) inhibited various human cancer cell growth in vitro and in vivo, including osteosarcoma cell growth in vitro, there has been no report on whether knock-down of GLUT-1 by siRNA may inhibit osteosarcoma cell growth in vivo. We hypothesized that siRNA may inhibit osteosarcoma cell growth in vivo. We introduced siRNA-GLUT-1 by lentivirus into MG63 osteosarcoma cells which were xenograted into nude mice. Immunohistochemical staining, Western blot and reverse transcriptase quantitative (RT-qPCR) were used to determine GLUT-1 protein and mRNA expression of the tumor cells. The results showed the tumor volume of GLUT-1-siRNA-MG63 cells xenorafted nude mice was significantly less than that of siGFP-MG63 or MG63 cells xenografted nude mice (P < 0.05), suggesting that silencing of GLUT-1 inhibited tumor formation and growth of osteosarcoma cells in vivo. Our findings suggest that the lentiviral-mediated siRNA interference against GLUT-1 may be a valuable tool for gene therapy for osteosarcoma.
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[frequency of next (right) word to tumor]
(1)36 cells (17)6 size (33)3 lysis (49)2 progression,
(2)23 suppressor (18)6 suppression (34)3 onset (50)2 recurred
(3)22 progression (19)6 tissue (35)3 targeting (51)2 recurrence
(4)20 necrosis (20)6 with (36)3 to (52)2 regression
(5)19 *null* (21)5 angiogenesis (37)3 types (53)2 response
(6)17 growth (22)5 initiating (38)2 1 (54)2 samples,
(7)15 cell (23)5 suppressive (39)2 activity (55)2 site
(8)14 was (24)5 volume (40)2 burden (56)2 size,
(9)12 and (25)4 model (41)2 classification (57)2 that
(10)11 development (26)4 sites (42)2 composed (58)2 the
(11)11 in (27)4 suppressors (43)2 expression (59)2 tissue,
(12)11 of (28)3 effects (44)2 heterogeneity (60)2 tissues
(13)7 microenvironment (29)3 excision (45)2 invasion (61)2 treatment
(14)6 formation (30)3 extension (46)2 is
(15)6 promotion (31)3 had (47)2 metastasis
(16)6 samples (32)3 local (48)2 mice

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--- WordNet output for tumor --- =>膨らみ, 出っ張り, 腫瘍 Overview of noun tumor The noun tumor has 1 sense (first 1 from tagged texts) 1. (18) tumor, tumour, neoplasm -- (an abnormal new mass of tissue that serves no purpose) --- WordNet end ---