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305909 occurrences (No.73 in the rank) during 5 years in the PubMed. [cache]
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305909 occurrences (No.73 in the rank) during 5 years in the PubMed. [cache]
| 178) Here, using patient tumors and cancer cell lines, we identify the NF-κB regulator, TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2), as an oncogene that is recurrently amplified and rearranged in 15% of human epithelial cancers. |
| PMID:24362534 DOI:10.1038/onc.2013.543 |
| 2015 Oncogene |
| * TRAF2 is an NF-κB-activating oncogene in epithelial cancers. |
| - Aberrant nuclear factor (NF)-κB activation is frequently observed in human cancers. Genome characterization efforts have identified genetic alterations in multiple components of the NF-κB pathway, some of which have been shown to be essential for cancer initiation and tumor maintenance. Here, using patient tumors and cancer cell lines, we identify the NF-κB regulator, TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2), as an oncogene that is recurrently amplified and rearranged in 15% of human epithelial cancers. Suppression of TRAF2 in cancer cells harboring TRAF2 copy number gain inhibits proliferation, NF-κB activation, anchorage-independent growth and tumorigenesis. Cancer cells that are dependent on TRAF2 also require NF-κB for survival. The phosphorylation of TRAF2 at serine 11 is essential for the survival of cancer cells harboring TRAF2 amplification. Together, these observations identify TRAF2 as a frequently amplified oncogene. |
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(1)36  cells |
(17)6 size |
(33)3 lysis |
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| (2)23 suppressor |
(18)6 suppression |
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| (3)22 progression |
(19)6 tissue |
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(52)2 regression |
| (5)19 *null* | (21)5 angiogenesis |
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| (6)17 growth |
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(38)2 1 |
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| (7)15 cell |
(23)5 suppressive |
(39)2 activity |
(55)2 site |
| (8)14 was |
(24)5 volume |
(40)2 burden |
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| (9)12 and |
(25)4 model |
(41)2 classification |
(57)2 that |
| (10)11 development |
(26)4 sites |
(42)2 composed |
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| (11)11 in |
(27)4 suppressors |
(43)2 expression |
(59)2 tissue, |
| (12)11 of |
(28)3 effects |
(44)2 heterogeneity |
(60)2 tissues |
| (13)7 microenvironment |
(29)3 excision |
(45)2 invasion |
(61)2 treatment |
| (14)6 formation |
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| (15)6 promotion |
(31)3 had |
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| (16)6 samples |
(32)3 local |
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--- WordNet output for tumor ---