2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
* Effect of dalteparin on atherosclerotic lesion formation in apolipoprotein E-deficient mice.
- We aimed to investigate whether prolonged treatment with dalteparin could inhibit plaque progression. With C57BL/6J mice as the control, genetically deficient apolipoprotein E (apo E) male mice of C57BL/6J strain (apo E(-/-)) were randomly divided into 3 groups. The model group received no dalteparin, while the other 2 groups received dalteparin at 100 and 200 U/kg d, respectively. The aorta was harvested for hematoxylin and eosin staining to observe plaque formation and for immunohistochemical staining to detect the expression of oxidized low-density lipoprotein receptor 1 (LOX-1). The expression of LOX-1 messenger RNA was detected by reverse transcription polymerase chain reaction, while the expression of LOX-1 protein was detected by Western blotting. Dalteparin decreased aortic plaque volume and inhibited aortic LOX-1 protein expression in apo E(-/-) mice. The effect persisted 4 weeks after dalteparin treatment was discontinued. Dalteparin may inhibit atherosclerotic lesions by downregulating the expression of LOX-1 protein.
=>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ
Overview of noun treatment
The noun treatment has 4 senses (first 4 from tagged texts)
1. (28) treatment, intervention -- (care provided to improve a situation (especially medical
procedures or applications that are intended to relieve illness or injury))
2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners";
"the treatment of water sewage"; "the right to equal treatment in the criminal justice system")
3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space
borrows from Italian architecture")
4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing
with some particular topic; "the book contains an excellent discussion of modal logic"; "his
treatment of the race question is badly biased")
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