kwic
treatment
treatment
right
off
ON
11
1
100
500
strict
ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for treatment out of >500 occurrences
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to treatment]
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 11) However, its pathophysiology is not yet fully elucidated, and effective treatment of BRONJ remains unclear. |
| PMID:23835780 DOI:10.1007/s10103-013-1382-6 |
| 2015 Lasers in medical science |
| * Effect of low-level laser therapy on oral keratinocytes exposed to bisphosphonate. |
| - Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of bisphosphonate therapy. However, its pathophysiology is not yet fully elucidated, and effective treatment of BRONJ remains unclear. The aim of this study is to investigate the effects of alendronate on oral keratinocytes and of low-level laser therapy (LLLT) on alendronate-treated keratinocytes, specifically by evaluating their viability, apoptosis, and wound healing function after irradiation. Oral keratinocyte cells (HaCaT) were exposed to 25 μM alendronate. Then, laser irradiation was performed with a low-level Ga-Al-As laser (λ = 808 ± 3 nm, 80 mW, and 80 mA; NDLux, Seoul, Korea) using 1.2 J/cm(2) energy dose. Viability was analyzed using MTT assay. Apoptosis was measured by Hoechst staining, caspase assay. Changes in secretion of IL-8, VEGF, and collagen type I were studied by ELISA and immunofluorescence microscopy. Scratch wound assays were also performed to measure cellular migration. Our results show that alendronate inhibits keratinocyte viability, expression of IL-8, VEGF, and collagen type I which are intimately related to healing events and cell migration while promoting apoptosis. Our results serve to demonstrate the utility of LLLT in partially overcoming the inhibitory effects of this bisphosphonate. From these results, the authors believe that the present study will provide an experimental basis for a fuller explanation of the clinical effects of LLLT as a BRONJ treatment modality. |
[
right
kwic]
(1)101  of |
(14)4 showed |
(27)3 the |
(40)2 leads |
| (2)53 *null* | (15)4 were |
(28)3 to |
(41)2 led |
| (3)38 with |
(16)3 as |
(29)3 without |
(42)2 may |
| (4)29 for |
(17)3 by |
(30)2 after |
(43)2 program |
| (5)23 and |
(18)3 cycle |
(31)2 also |
(44)2 protocols |
| (6)11 in |
(19)3 group |
(32)2 are |
(45)2 response |
| (7)9 was |
(20)3 modalities |
(33)2 can |
(46)2 schizophrenia |
| (8)6 groups |
(21)3 on |
(34)2 concentration |
(47)2 seems |
| (9)6 options |
(22)3 option |
(35)2 cycles |
(48)2 significantly |
| (10)5 or |
(23)3 outcomes |
(36)2 effects |
(49)2 strategies |
| (11)4 allocation |
(24)3 period |
(37)2 group, |
|
| (12)4 completion |
(25)3 plants |
(38)2 induced |
|
| (13)4 effect |
(26)3 success |
(39)2 is |
add keyword
--- WordNet output for treatment ---