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321) Furthermore, this reduction in Young's modulus with U0126 treatment during hydrostatic pressure application corresponded to a decrease in total collagen expression.
2015 Journal of tissue engineering and regenerative medicine
* ERK activation is required for hydrostatic pressure-induced tensile changes in engineered articular cartilage.
- The objective of this study was to identify ERK 1/2 involvement in the changes in compressive and tensile mechanical properties associated with hydrostatic pressure treatment of self-assembled cartilage constructs. In study 1, ERK 1/2 phosphorylation was detected by immunoblot, following application of hydrostatic pressure (1 h of static 10 MPa) applied at days 10-14 of self-assembly culture. In study 2, ERK 1/2 activation was blocked during hydrostatic pressure application on days 10-14. With pharmacological inhibition of the ERK pathway by the MEK1/ERK inhibitor U0126 during hydrostatic pressure application on days 10-14, the increase in Young's modulus induced by hydrostatic pressure was blocked. Furthermore, this reduction in Young's modulus with U0126 treatment during hydrostatic pressure application corresponded to a decrease in total collagen expression. However, U0126 did not inhibit the increase in aggregate modulus or GAG induced by hydrostatic pressure. These findings demonstrate a link between hydrostatic pressure application, ERK signalling and changes in the biomechanical properties of a tissue-engineered construct.
=>1.(車が)全壊する, 全損する, 2.全体の, 全ての, 総計の, 総体の, 全くの, 完全な, 総力の, 3.総額, 総計,
全体の, (車が)全壊する, 合計(する), なる
Overview of noun total
The noun total has 2 senses (first 2 from tagged texts)
1. (13) sum, total, totality, aggregate -- (the whole amount)
2. (6) sum, amount, total -- (a quantity obtained by the addition of a group of numbers)
Overview of verb total
The verb total has 3 senses (first 2 from tagged texts)
1. (16) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to
$2,000"; "The bill came to $2,000")
2. (2) total, tot, tot up, sum, sum up, summate, tote up, add, add together, tally, add up --
(determine the sum of; "Add all the people in this town to those of the neighboring town")
3. total -- (damage beyond the point of repair; "My son totaled our new car"; "the rock star totals
his guitar at every concert")
Overview of adj total
The adj total has 2 senses (first 2 from tagged texts)
1. (31) entire, full, total -- (constituting the full quantity or extent; complete; "an entire town
devastated by an earthquake"; "gave full attention"; "a total failure")
2. (2) full, total -- (complete in extent or degree and in every particular; "a full game"; "a total
eclipse"; "a total disaster")
--- WordNet end ---