* Hypermethylation of P15, P16, and E-cadherin genes in ovarian cancer.
- Both p16 and p15 proteins are inhibitors of cyclin-dependent kinases that prevent the cell going through the G1/S phase transaction. E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent interactions between adjacent epithelial cells. Two groups of patients were selected: the first group suffered from epithelial serous ovarian tumors and the second group suffered from benign ovarian lesions; ovarian tissue samples from all the subjects (benign and malignant) were subjected to methylation-specific polymerase chain reaction for methylated and unmethylated alleles of the genes (E-cadherin, p15, and p16). Results obtained showed that aberrant methylation of p15 and p16 genes were detected in 64.29 and 50% of ovarian cancer patients, while E-cadherin hypermethylation was detected in 78.57% of ovarian cancer patients. Methylation of E-cadherin was significantly correlated with different stage of disease (p < 0.05). It was found that the risk of E-cadherin hypermethylation was 1.347-fold, while risk of p15 hypermethylation was 1.543-fold and p16 was 1.2-fold among patients with ovarian cancer than that among patients with benign ovarian lesions. In conclusion, Dysfunction of the cell cycle and/or the cell-cell adhesion molecule plays a role in the pathogenesis of ovarian cancer and that the analysis of the methylation of p15 and E-cadherin genes can provide clinically important evidence on which to base the treatment.
=>直通の, のために, の間じゅう, 終わって, を貫いて, の中を通って, のいたるところに, を通じて
Overview of adj through
The adj through has 2 senses (first 1 from tagged texts)
1. (4) done, through, through with -- (having finished or arrived at completion; "certain to make
history before he's done"; "it's a done deed"; "after the treatment, the patient is through except
for follow-up"; "almost through with his studies")
2. through -- ((of a route or journey etc.) continuing without requiring stops or changes; "a
through street"; "a through bus"; "through traffic")
Overview of adv through
The adv through has 5 senses (first 3 from tagged texts)
1. (5) through -- (from beginning to end; "read this book through")
2. (2) through -- (over the whole distance; "this bus goes through to New York")
3. (1) through -- (to completion; "think this through very carefully!")
4. through -- (in diameter; "this cylinder measures 15 inches through")
5. through, through and through -- (throughout the entire extent; "got soaked through in the rain";
"I'm frozen through"; "a letter shot through with the writer's personality"; "knew him through and
through"; "boards rotten through and through")
--- WordNet end ---