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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

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303636 occurrences (No.74 in the rank) during 5 years in the PubMed. [no cache] 500 found
339) The review is organised with a comparative focus on the functional domains of motor control, cognition and behavioural disturbance (akin to psychiatric disturbance in people) and how our knowledge of the underlying physiological changes that are manifest in the HD mouse lines correspond to those seen in the HD clinical population.
--- ABSTRACT ---
PMID:24357436 DOI:10.1007/7854_2013_256
2015 Current topics in behavioral neurosciences
* Mouse Models of Huntington's Disease.
- In this review, we explore the similarities and differences in the behavioural neurobiology found in the mouse models of Huntington's disease (HD) and the human disease state. The review is organised with a comparative focus on the functional domains of motor control, cognition and behavioural disturbance (akin to psychiatric disturbance in people) and how our knowledge of the underlying physiological changes that are manifest in the HD mouse lines correspond to those seen in the HD clinical population. The review is framed in terms of functional circuitry and neurotransmitter systems and how abnormalities in these systems impact on the behavioural readouts across the mouse lines and how these may correspond to the deficits observed in people. In addition, interpretational issues associated with the data from animal studies are discussed.
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