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return kwic search for system out of >500 occurrences
331253 occurrences (No.58 in the rank) during 5 years in the PubMed. [no cache] 500 found

196) In this study, we established an in vitro engineered microenvironment: i.e., a tissue test system that combined heterocellular tumour spheroids, polymeric microcarriers and adipocytes, an abundant stromal cell type in breast tissue, to investigate the behaviour of breast cancer cells in response to different environmental stimuli in a more relevant 3D microenvironment.

--- ABSTRACT ---

PMID:23307775 DOI:10.1002/term.1660

2015 Journal of tissue engineering and regenerative medicine

* Designing a tunable 3D heterocellular breast cancer tissue test system.

- It is increasingly recognized that the tissue microenvironment is crucial in cell signaling and regulation of normal and malignant cell function. Components and properties of the microenvironment such as extracellular matrix, adhesion integrins, tissue architectures and tissue modulus regulate growth, differentiation and apoptosis of cells. These properties control cell fate through complex signals that are influenced either by interactions between neighbouring cells or by stimulated cell surface receptors. In this study, we established an in vitro engineered microenvironment: i.e., a tissue test system that combined heterocellular tumour spheroids, polymeric microcarriers and adipocytes, an abundant stromal cell type in breast tissue, to investigate the behaviour of breast cancer cells in response to different environmental stimuli in a more relevant 3D microenvironment. Results showed the engineered microenvironment influenced breast cancer cell proliferation, differentiation and migration through multi-cellular interactions and changes in microenvironmental stiffness and that stromal cells such as adipocytes play a critical role in the breast cancer process.

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(1)88 null	(12)6 by	(23)3 (ANS)	(34)2 diseases
(2)30 and	(13)6 has	(24)3 (CNS)	(35)2 including
(3)19 is	(14)5 are	(25)3 a	(36)2 involvement
(4)18 of	(15)5 might	(26)3 after	(37)2 known
(5)18 was	(16)5 the	(27)3 as	(38)2 on
(6)17 in	(17)4 Adhesive	(28)3 based	(39)2 one
(7)16 that	(18)4 can	(29)3 development	(40)2 plays
(8)15 for	(19)4 have	(30)3 we	(41)2 related
(9)13 to	(20)4 may	(31)2 (GIS)	(42)2 results
(10)8 which	(21)4 using	(32)2 containing	(43)2 used
(11)7 with	(22)4 were	(33)2 demonstrated

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--- WordNet output for system --- =>制度組織体系的方式, システム, 組織, 整然とした手順, (思想などの)体系, 体制 Overview of noun system The noun system has 9 senses (first 8 from tagged texts) 1. (43) system -- (instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer") 2. (23) system, scheme -- (a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going") 3. (14) system -- ((physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide") 4. (10) system, system of rules -- (a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender") 5. (8) arrangement, organization, organisation, system -- (an organized structure for arranging or classifying; "he changed the arrangement of the topics"; "the facts were familiar but it was in the organization of them that he was original"; "he tried to understand their system of classification") 6. (7) system -- (a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion") 7. (6) system -- (a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation") 8. (1) system -- (the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system") 9. organization, organisation, system -- (an ordered manner; orderliness by virtue of being methodical and well organized; "his compulsive organization was not an endearing quality"; "we can't do it unless we establish some system around here") --- WordNet end ---