ELIZA

return kwic search for study, out of >500 occurrences
300943 occurrences (No.75 in the rank) during 5 years in the PubMed. [no cache] 500 found

413) In this study, Pasteurella multocida-loaded alginate microparticles (MPs) for subcutaneous vaccination was developed by emulsification-cross-linking technique.

--- ABSTRACT ---

PMID:24378199 DOI:10.3109/03639045.2013.873448

2015 Drug development and industrial pharmacy

* Development of Pasteurella multocida-loaded microparticles for hemorrhagic septicemia vaccine.

- In this study, Pasteurella multocida-loaded alginate microparticles (MPs) for subcutaneous vaccination was developed by emulsification-cross-linking technique. Formulation parameter was varied as a ratio of polymer and bacterin. Optical microscopy revealed spherical particles with uniformly distribution. A mean particle size of approximately 6 µm has been successfully constructed using simple mixer and ultrasonic probe. The zeta potential of the MPs showed negatively charge of approximately -23 mV determined by Zeta Pals® analyzer. The entrapment efficiency and the in vitro bacterin released profile could be controlled by varying the amount of alginate. The high entrapment efficiency up to 69% was achieved with low concentration of alginate. The MPs possessed a slow bacterin release profile, up to 30 days. In vivo safety and potency tests were proved that the alginate MPs were safe and induced protective immunity in mice. In addition, after storage for 6 months at either 4 °C or room temperature, the protective immunity in mice was maintained.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to study,]

(1)219 we	(6)6 two	(11)3 to	(16)2 human
(2)85 the	(7)4 which	(12)2 24	(17)2 in
(3)22 a	(8)3 DNA	(13)2 an	(18)2 serum
(4)11 and	(9)3 therefore,	(14)2 effects	(19)2 six
(5)8 it	(10)3 three	(15)2 further

add keyword

--- WordNet output for study, --- --- WordNet end ---