* [Measurement of d-dimers in non-valvular atrial fibrillation. First prospective Tunisian study].
- Atrial fibrillation can expose to thrombo-embolic complications. Many biomarkers have been tested to refine the stratification of thrombo-embolic risk. The study aim was to assess the interest of the d-dimer testing in this pathology. We conducted a prospective observational study including 50 cases and 19 controls, enrolled at the cardiology department of the Mongi Slim Hospital, from July to November 2012. The d-dimer assay was performed on mini-VIDAS(®) and analyzed according to clinical, echocardiographic and biological data. The mean age of patients was 61.8±10.6years. The mean CHA2DS2-VASc score was 2.58±1.31. The average of D-dimer levels was 590±506ng/ml in patients and 225.26±112.95ng/ml in controls (P=0.02). No significant difference has been found between the d-dimer level and age, sex, type and etiology of atrial fibrillation, the CHA2DS2-VASc score, the left atrial surface. Among patients on acenocoumarol, d-dimer levels was significantly higher in patients with an INR<2 compared to those with an INR≥2 (P=0.004). We identified a positive d-dimer threshold (300ng/ml) in patients distinguishing them significantly with controls (P<0.001). In conclusion, the measurement of d-dimers could help clinicians to identify patients with atrial fibrillation having an increased coagulability and, therefore, an increased thrombo-embolic risk. It could be complementary to the determination of INR in monitoring anticoagulation therapy: d-dimers level refines the thrombo-embolic risk and INR measurement assesses the level of anticoagulation and the bleeding risk.
=>1.〜を勉強[研究]する, 学ぶ, 調べる, 2.調査, 勉強, 3.書斎, 勉強する
Overview of noun study
The noun study has 10 senses (first 8 from tagged texts)
1. (90) survey, study -- (a detailed critical inspection)
2. (17) study, work -- (applying the mind to learning and understanding a subject (especially by
reading); "mastering a second language requires a lot of work"; "no schools offer graduate study in
interior design")
3. (6) report, study, written report -- (a written document describing the findings of some
individual or group; "this accords with the recent study by Hill and Dale")
4. (6) study -- (a state of deep mental absorption; "she is in a deep study")
5. (6) study -- (a room used for reading and writing and studying; "he knocked lightly on the closed
door of the study")
6. (3) discipline, subject, subject area, subject field, field, field of study, study, bailiwick --
(a branch of knowledge; "in what discipline is his doctorate?"; "teachers should be well trained in
their subject"; "anthropology is the study of human beings")
7. (2) sketch, study -- (preliminary drawing for later elaboration; "he made several studies before
starting to paint")
8. (1) cogitation, study -- (attentive consideration and meditation; "after much cogitation he
rejected the offer")
9. study -- (someone who memorizes quickly and easily (as the lines for a part in a play); "he is a
quick study")
10. study -- (a composition intended to develop one aspect of the performer's technique; "a study in
spiccato bowing")
Overview of verb study
The verb study has 6 senses (first 6 from tagged texts)
1. (73) analyze, analyse, study, examine, canvass, canvas -- (consider in detail and subject to an
analysis in order to discover essential features or meaning; "analyze a sonnet by Shakespeare";
"analyze the evidence in a criminal trial"; "analyze your real motives")
2. (17) study -- (be a student; follow a course of study; be enrolled at an institute of learning)
3. (15) study, consider -- (give careful consideration to; "consider the possibility of moving")
4. (13) learn, study, read, take -- (be a student of a certain subject; "She is reading for the bar
exam")
5. (5) study, hit the books -- (learn by reading books; "He is studying geology in his room"; "I
have an exam next week; I must hit the books now")
6. (2) study, meditate, contemplate -- (think intently and at length, as for spiritual purposes; "He
is meditating in his study")
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