ELIZA

return kwic search for study out of >500 occurrences
1099112 occurrences (No.1 in the rank) during 5 years in the PubMed. [cache]

248) This study examined the treatment of penetrating brain injury (PBI) in a rat model with collagen biomaterials and a soluble Nogo receptor (sNgR) molecule.

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PMID:23038669 DOI:10.1002/term.1621

2015 Journal of tissue engineering and regenerative medicine

* Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptor.

- Injuries and diseases of the central nervous system (CNS) have the potential to cause permanent loss of brain parenchyma, with severe neurological consequences. Cavitary defects in the brain may afford the possibility of treatment with biomaterials that fill the lesion site while delivering therapeutic agents. This study examined the treatment of penetrating brain injury (PBI) in a rat model with collagen biomaterials and a soluble Nogo receptor (sNgR) molecule. sNgR was aimed at neutralizing myelin proteins that hinder axon regeneration by inducing growth cone collapse. Scaffolds containing sNgR were implanted in the brains of adult rats 1 week after injury and analysed 4 weeks or 8 weeks later. Histological analysis revealed that the scaffolds filled the lesion sites, remained intact with open pores and were infiltrated with cells and extracellular matrix. Immunohistochemical staining demonstrated the composition of the cellular infiltrate to include macrophages, astrocytes and vascular endothelial cells. Isolated regions of the scaffold borders showed integration with surrounding viable brain tissue that included neurons and oligodendrocytes. While axon regeneration was not detected in the scaffolds, the cellular infiltration and vascularization of the lesion site demonstrated a modification of the injury environment with implications for regenerative strategies.

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[frequency of next (right) word to study]

(1)109 was	(16)6 used	(31)2 1	(46)2 investigates
(2)36 we	(17)5 included	(32)2 and	(47)2 it
(3)25 aimed	(18)5 showed	(33)2 as	(48)2 objective
(4)24 null	(19)5 subjects	(34)2 assessed	(49)2 participants
(5)15 the	(20)4 a	(35)2 compared	(50)2 period
(6)14 investigated	(21)4 also	(36)2 data	(51)2 provide
(7)14 is	(22)4 demonstrates	(37)2 demonstrated	(52)2 provided
(8)13 examined	(23)4 explored	(38)2 determined	(53)2 provides
(9)9 aims	(24)4 found	(39)2 evaluated	(54)2 recommends
(10)9 were	(25)4 on	(40)2 evaluates	(55)2 reveals
(11)8 of	(26)3 examines	(41)2 findings	(56)2 suggest
(12)8 suggests	(27)3 period,	(42)2 has	(57)2 three
(13)7 to	(28)3 population	(43)2 have
(14)6 in	(29)3 revealed	(44)2 highlighted
(15)6 may	(30)3 shows	(45)2 highlights

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--- WordNet output for study --- =>1.〜を勉強[研究]する, 学ぶ, 調べる, 2.調査, 勉強, 3.書斎, 勉強する Overview of noun study The noun study has 10 senses (first 8 from tagged texts) 1. (90) survey, study -- (a detailed critical inspection) 2. (17) study, work -- (applying the mind to learning and understanding a subject (especially by reading); "mastering a second language requires a lot of work"; "no schools offer graduate study in interior design") 3. (6) report, study, written report -- (a written document describing the findings of some individual or group; "this accords with the recent study by Hill and Dale") 4. (6) study -- (a state of deep mental absorption; "she is in a deep study") 5. (6) study -- (a room used for reading and writing and studying; "he knocked lightly on the closed door of the study") 6. (3) discipline, subject, subject area, subject field, field, field of study, study, bailiwick -- (a branch of knowledge; "in what discipline is his doctorate?"; "teachers should be well trained in their subject"; "anthropology is the study of human beings") 7. (2) sketch, study -- (preliminary drawing for later elaboration; "he made several studies before starting to paint") 8. (1) cogitation, study -- (attentive consideration and meditation; "after much cogitation he rejected the offer") 9. study -- (someone who memorizes quickly and easily (as the lines for a part in a play); "he is a quick study") 10. study -- (a composition intended to develop one aspect of the performer's technique; "a study in spiccato bowing") Overview of verb study The verb study has 6 senses (first 6 from tagged texts) 1. (73) analyze, analyse, study, examine, canvass, canvas -- (consider in detail and subject to an analysis in order to discover essential features or meaning; "analyze a sonnet by Shakespeare"; "analyze the evidence in a criminal trial"; "analyze your real motives") 2. (17) study -- (be a student; follow a course of study; be enrolled at an institute of learning) 3. (15) study, consider -- (give careful consideration to; "consider the possibility of moving") 4. (13) learn, study, read, take -- (be a student of a certain subject; "She is reading for the bar exam") 5. (5) study, hit the books -- (learn by reading books; "He is studying geology in his room"; "I have an exam next week; I must hit the books now") 6. (2) study, meditate, contemplate -- (think intently and at length, as for spiritual purposes; "He is meditating in his study") --- WordNet end ---