ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for study aim out of >500 occurrences
45414 occurrences (No.1558 in the rank) during 5 years in the PubMed. [cache]
2) Study aim was to determine if cardiovascular-related circulating microRNA (miRNA) are altered following HDBR and if they relate to changes in cardiac function and peak aerobic capacity.
--- ABSTRACT ---
PMID:31087541 DOI:10.14814/phy2.14061
Physiological reports 2019
* Differential MicroRNA expression following head-down tilt bed rest: implications for cardiovascular responses to microgravity.
- Head-down tilt bedrest (HDBR), an analog of spaceflight, elicits changes in cardiovascular function that adversely affect astronaut performance. It is therefore fundamental to elucidate the molecular regulators of these changes. Study aim was to determine if cardiovascular-related circulating microRNA (miRNA) are altered following HDBR and if they relate to changes in cardiac function and peak aerobic capacity. Eleven participants completed 30-days HDBR at an ambient CO2 of 0.5% (replicate the in-flight CO2 levels). Blood samples were obtained 3 days (BDC-3) prior to and immediately (R + 0) following HDBR. 44-targeted circulating miRNAs (c-miRNA) identified from published roles in cardiovascular structure/function were analyzed via RT-qPCR. Resting stroke volume was evaluated via ultrasonography. Peak oxygen uptake ( V ˙ O 2 peak ) was determined using a graded exercise test on an electronically braked cycle ergometer. Ten cardiovascular-related miRNA were significantly increased following HDBR. The differentially expressed c-miRNA were grouped into clusters according to their expression profile. Cluster A included c-miRNA that have been identified as regulators of cardiac function and hypertrophy (c-miRNA-133), atrial fibrillation and mitochondrial function (c-miRNA-1), skeletal muscle atrophy (c-miRNA-1), and vascular control (c-miRNA-155). Cluster B contained c-miRNA identified as regulators of cardiac hypertrophy (c-miRNA-30, -15), fibrosis (c-miRNA-22, -18), mitochondrial function (miRNA-181), and aerobic capacity (c-miRNA-20a). Following HDBR resting stroke volume was decreased and correlated with changes in c-miRNA-378a and -18a. V ˙ O 2 peak was decreased and correlated with changes c-miRNA-133. In conclusion, we found that HDBR induced a distinct and specific cardiovascular-related miRNA response, which were associated with changes in cardiac function and peak aerobic capacity.
[frequency of next (right) word to study aim]
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(2)56 to (6)4 The (10)3 or
(3)27 is (7)3 Endoscopic (11)2 In
(4)8 *null* (8)3 and (12)2 To

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--- WordNet output for study --- =>1.〜を勉強[研究]する, 学ぶ, 調べる, 2.調査, 勉強, 3.書斎, 勉強する Overview of noun study The noun study has 10 senses (first 8 from tagged texts) 1. (90) survey, study -- (a detailed critical inspection) 2. (17) study, work -- (applying the mind to learning and understanding a subject (especially by reading); "mastering a second language requires a lot of work"; "no schools offer graduate study in interior design") 3. (6) report, study, written report -- (a written document describing the findings of some individual or group; "this accords with the recent study by Hill and Dale") 4. (6) study -- (a state of deep mental absorption; "she is in a deep study") 5. (6) study -- (a room used for reading and writing and studying; "he knocked lightly on the closed door of the study") 6. (3) discipline, subject, subject area, subject field, field, field of study, study, bailiwick -- (a branch of knowledge; "in what discipline is his doctorate?"; "teachers should be well trained in their subject"; "anthropology is the study of human beings") 7. (2) sketch, study -- (preliminary drawing for later elaboration; "he made several studies before starting to paint") 8. (1) cogitation, study -- (attentive consideration and meditation; "after much cogitation he rejected the offer") 9. study -- (someone who memorizes quickly and easily (as the lines for a part in a play); "he is a quick study") 10. study -- (a composition intended to develop one aspect of the performer's technique; "a study in spiccato bowing") Overview of verb study The verb study has 6 senses (first 6 from tagged texts) 1. (73) analyze, analyse, study, examine, canvass, canvas -- (consider in detail and subject to an analysis in order to discover essential features or meaning; "analyze a sonnet by Shakespeare"; "analyze the evidence in a criminal trial"; "analyze your real motives") 2. (17) study -- (be a student; follow a course of study; be enrolled at an institute of learning) 3. (15) study, consider -- (give careful consideration to; "consider the possibility of moving") 4. (13) learn, study, read, take -- (be a student of a certain subject; "She is reading for the bar exam") 5. (5) study, hit the books -- (learn by reading books; "He is studying geology in his room"; "I have an exam next week; I must hit the books now") 6. (2) study, meditate, contemplate -- (think intently and at length, as for spiritual purposes; "He is meditating in his study") --- WordNet end ---