* Comparison of mitotic index and Ki67 index in the prognostication of canine cutaneous mast cell tumours.
- Proliferation markers are commonly used for prognostication of mast cell tumours. The aim of the study is to compare the relative abilities of Ki67 and mitotic index to predict survival in the same cohort of dogs with cutaneous MCTs. Histological grade, mitotic index and Ki67 index were performed in all samples and clinical information was obtained by a follow-up questionnaire. Ninety-five dogs were included in the study with a median follow-up of 1145 days. Survival times varied significantly between categories of histological grade, mitotic index and Ki67 index. Multivariable analyses showed that the risk of dying due to MCT was similar in dogs with increased Ki67 index [hazard ratio, HR: 3.0 (95% CI 1.3-6.8)] or increased mitotic index [HR: 2.7 (95% CI 1.1-6.5)]. In conclusion, both mitotic index and Ki67 index were able to independently differentiate MCTs with worse prognosis. This distinction is particularly meaningful in selecting intermediate grade MCTs that may benefit from more aggressive local or systemic treatment.
=>きわめて, 意味深く, 意味ありげに
Overview of adv significantly
The adv significantly has 3 senses (first 2 from tagged texts)
1. (6) significantly -- (in a statistically significant way; "the two groups differed
significantly")
2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by
these new cuts")
3. importantly, significantly -- (in an important way or to an important degree; "more importantly,
Weber held that the manifold meaning attached to the event by the social scientist could alter his
definition of the concrete event itself")
--- WordNet end ---