ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for significantly out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [cache]
367) Although wogonin expressed only weak inhibitory effect on LPS-/INF-γ-induced phosphorylation of Janus kinase-2 (Jak-2) and tyrosine kinase (Tyk)-2, it significantly attenuated the phosphorylation of Jak-1 and Jak-3.
--- ABSTRACT ---
PMID:23592745 DOI:10.1177/0748233713485886
2015 Toxicology and industrial health
* Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells.
- Wogonin is a flavonoid compound which exhibits antioxidation, anti-inflammation, neuroprotection, and antitumorgenesis functions. However, the mechanism of how wogonin reduces proinflammatory cytokine generation in activated microglia is unclear. At present, we found wogonin inhibited lipopolysaccharide (LPS)-/interferon-γ (INF-γ)-induced generation of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Wogonin exhibited parallel inhibition on LPS-/INF-γ-induced expression of IL-6 and TNF-α messenger RNA at the same concentration range. LPS-/INF-γ-induced phosphorylation of signal transduction and transcription 1 and 3 (STAT1/3) were also inhibited by wogonin. Although wogonin expressed only weak inhibitory effect on LPS-/INF-γ-induced phosphorylation of Janus kinase-2 (Jak-2) and tyrosine kinase (Tyk)-2, it significantly attenuated the phosphorylation of Jak-1 and Jak-3. These results indicated that the blockade of IL-6 and TNF-α production by wogonin in LPS-/INF-γ-stimulated BV2 microglial cells was attributed mainly to the interference in Jak-1/-3-STAT1/3 signaling pathway.
--- ABSTRACT END ---
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[frequency of next (right) word to significantly]
(1)88 higher (13)8 improved (25)3 (P<0.05) (39)2 impaired
(2)43 lower (14)6 correlated (27)3 affect (40)2 increases
(3)39 increased (15)6 elevated (28)3 better (41)2 induced
(4)35 reduced (16)6 fewer (29)3 increase (42)2 larger
(5)32 associated (17)6 less (30)3 worse (43)2 predicted
(6)17 decreased (18)5 enhanced (31)2 (P (44)2 reduce
(7)13 in (19)5 inhibited (32)2 (p (45)2 shorter
(8)13 more (20)4 affected (34)2 altered (46)2 smaller
(9)10 greater (21)4 attenuated (35)2 by (47)2 suppressed
(10)10 related (22)4 between (36)2 compared (48)2 to
(11)9 *null* (23)4 from (37)2 decreased,
(12)9 different (24)4 the (38)2 differed

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--- WordNet output for significantly --- =>きわめて, 意味深く, 意味ありげに Overview of adv significantly The adv significantly has 3 senses (first 2 from tagged texts) 1. (6) significantly -- (in a statistically significant way; "the two groups differed significantly") 2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by these new cuts") 3. importantly, significantly -- (in an important way or to an important degree; "more importantly, Weber held that the manifold meaning attached to the event by the social scientist could alter his definition of the concrete event itself") --- WordNet end ---