ELIZA

return kwic search for significantly out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [cache]

337) The plasma viscosity was significantly elevated in the subgroups.

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PMID:23709227 DOI:10.1177/0748233713491804

2015 Toxicology and industrial health

* The effect of occupational lead exposure on lipid peroxidation, protein carbonylation, and plasma viscosity.

- The aim of the study was to investigate the influence of occupational lead (Pb) exposure on lipid peroxidation, protein carbonylation, and plasma viscosity in workers. The examined group included 283 healthy male employees of manufacturing facilities using zinc and Pb. The mean blood concentrations of Pb and zinc protoporphyrin as well as the mean urine δ-aminolevulinic acid levels were used as markers of exposure for the examined group. Taking into account the obtained mean values of blood lead level, the examined group was divided into three subgroups. When comparing the control group with the subgroups, Pb exposure markers were significantly elevated in all the three subgroups. Concentrations of conjugated dienes (CD), lipid hydroperoxides, malondialdehyde (MDA), and protein carbonyl groups were also significantly increased. Conversely, the levels of total protein and protein sulfhydryls were significantly decreased in the subgroups compared with the controls. The plasma viscosity was significantly elevated in the subgroups. A dose-response between Pb levels and plasma viscosity was not observed. Pb supposedly elevates MDA and CD in a dose-dependent manner. In conclusion, occupational Pb exposure induces oxidative stress that results in lipid and protein damage. Moreover, Pb-induced oxidative stress is likely the primary factor that elevates plasma viscosity, despite decreased protein levels.

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[frequency of next (right) word to significantly]

(1)88 higher	(13)8 improved	(25)3 (P<0.05)	(39)2 impaired
(2)43 lower	(14)6 correlated	(27)3 affect	(40)2 increases
(3)39 increased	(15)6 elevated	(28)3 better	(41)2 induced
(4)35 reduced	(16)6 fewer	(29)3 increase	(42)2 larger
(5)32 associated	(17)6 less	(30)3 worse	(43)2 predicted
(6)17 decreased	(18)5 enhanced	(31)2 (P	(44)2 reduce
(7)13 in	(19)5 inhibited	(32)2 (p	(45)2 shorter
(8)13 more	(20)4 affected	(34)2 altered	(46)2 smaller
(9)10 greater	(21)4 attenuated	(35)2 by	(47)2 suppressed
(10)10 related	(22)4 between	(36)2 compared	(48)2 to
(11)9 null	(23)4 from	(37)2 decreased,
(12)9 different	(24)4 the	(38)2 differed

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--- WordNet output for significantly --- =>きわめて, 意味深く, 意味ありげに Overview of adv significantly The adv significantly has 3 senses (first 2 from tagged texts) 1. (6) significantly -- (in a statistically significant way; "the two groups differed significantly") 2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by these new cuts") 3. importantly, significantly -- (in an important way or to an important degree; "more importantly, Weber held that the manifold meaning attached to the event by the social scientist could alter his definition of the concrete event itself") --- WordNet end ---