ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for significantly out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache]
500 found
225) TAMs, detected by MAC387 expression, were significantly associated with malignant CMT (P < 0.001) and VEGF positive tumours (P = 0.002) and also associated with VEGF expression within malignant CMT (P = 0.043).
* Tumour-associated macrophages are associated with vascular endothelial growth factor expression in canine mammary tumours.
- Tumour-associated macrophages (TAMs) have been implicated in carcinogenesis including an important role in angiogenesis. In this study, we describe the relationship between TAMs and angiogenesis in canine mammary tumours (CMT). Formalin-fixed paraffin-embedded CMT samples [(n = 128: malignant (n = 97) and benign (n = 31)] were submitted to immunohistochemical staining to detect MAC387, vascular endothelial growth factor VEGF and CD31 expression. A statistical analysis was carried out to assess possible associations with clinicopathological variables and biological markers of tumour angiogenesis. TAMs, detected by MAC387 expression, were significantly associated with malignant CMT (P < 0.001) and VEGF positive tumours (P = 0.002) and also associated with VEGF expression within malignant CMT (P = 0.043). Associations with clinicopathological variables were found between TAMs and the presence of infiltrative growth (P = 0.031), low tubule formation (P = 0.040) and lymph node metastasis (P = 0.016). The results support the hypothesis that TAMs influence angiogenesis in CMT suggesting TAMs may represent a therapeutic target in this disease.
=>きわめて, 意味深く, 意味ありげに
Overview of adv significantly
The adv significantly has 3 senses (first 2 from tagged texts)
1. (6) significantly -- (in a statistically significant way; "the two groups differed
significantly")
2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by
these new cuts")
3. importantly, significantly -- (in an important way or to an important degree; "more importantly,
Weber held that the manifold meaning attached to the event by the social scientist could alter his
definition of the concrete event itself")
--- WordNet end ---