ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for significantly out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [cache]
175) HyEc significantly reduced ASC migration.
--- ABSTRACT ---
PMID:23841674 DOI:10.1111/iwj.12120
2015 International wound journal
* Adipose-derived stem cells and keratinocytes in a chronic wound cell culture model: the role of hydroxyectoine.
- Chronic wounds represent a major socio-economic problem in developed countries today. Wound healing is a complex biological process. It requires a well-orchestrated interaction of mediators, resident cells and infiltrating cells. In this context, mesenchymal stem cells and keratinocytes play a crucial role in tissue regeneration. In chronic wounds these processes are disturbed and cell viability is reduced. Hydroxyectoine (HyEc) is a membrane protecting osmolyte with protein and macromolecule stabilising properties. Adipose-derived stem cells (ASC) and keratinocytes were cultured with chronic wound fluid (CWF) and treated with HyEc. Proliferation was investigated using MTT test and migration was examined with transwell-migration assay and scratch assay. Gene expression changes of basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), matrix metalloproteinases-2 (MMP-2) and MMP-9 were analysed by quantitative real-time polymerase chain reaction (qRT-PCR). CWF significantly inhibited proliferation and migration of keratinocytes. Addition of HyEc did not affect these results. Proliferation capacity of ASC was not influenced by CWF whereas migration was significantly enhanced. HyEc significantly reduced ASC migration. Expression of b-FGF, VEGF, MMP-2 and MMP-9 in ASC, and b-FGF, VEGF and MMP-9 in keratinocytes was strongly induced by chronic wound fluid. HyEc enhanced CWF induced gene expression of VEGF in ASC and MMP-9 in keratinocytes. CWF negatively impaired keratinocyte function, which was not influenced by HyEc. ASC migration was stimulated by CWF, whereas HyEc significantly inhibited migration of ASC. CWF induced gene expression of VEGF in ASC and MMP-9 in keratinocytes was enhanced by HyEc, which might partly be explained by an RNA stabilising effect of HyEc.
--- ABSTRACT END ---
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[frequency of next (right) word to significantly]
(1)88 higher (13)8 improved (25)3 (P<0.05) (39)2 impaired
(2)43 lower (14)6 correlated (27)3 affect (40)2 increases
(3)39 increased (15)6 elevated (28)3 better (41)2 induced
(4)35 reduced (16)6 fewer (29)3 increase (42)2 larger
(5)32 associated (17)6 less (30)3 worse (43)2 predicted
(6)17 decreased (18)5 enhanced (31)2 (P (44)2 reduce
(7)13 in (19)5 inhibited (32)2 (p (45)2 shorter
(8)13 more (20)4 affected (34)2 altered (46)2 smaller
(9)10 greater (21)4 attenuated (35)2 by (47)2 suppressed
(10)10 related (22)4 between (36)2 compared (48)2 to
(11)9 *null* (23)4 from (37)2 decreased,
(12)9 different (24)4 the (38)2 differed

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--- WordNet output for significantly --- =>きわめて, 意味深く, 意味ありげに Overview of adv significantly The adv significantly has 3 senses (first 2 from tagged texts) 1. (6) significantly -- (in a statistically significant way; "the two groups differed significantly") 2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by these new cuts") 3. importantly, significantly -- (in an important way or to an important degree; "more importantly, Weber held that the manifold meaning attached to the event by the social scientist could alter his definition of the concrete event itself") --- WordNet end ---