ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for significant out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found
75) The results of the experiment indicate that Al induced a statistically significant increase in Al and Fe concentrations in liver and serum as well as in Cu in the kidney.
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PMID:23625912 DOI:10.1177/0748233713486956
2015 Toxicology and industrial health
* Effects of aluminum chloride on some trace elements and erythrocyte osmotic fragility in rats.
- Aluminum (Al) is a nonessential, toxic element to which humans are constantly exposed as a result of an increase in industrialization and improving technology practices. The aim of the study was to investigate the effects of different durations and doses of Al exposure on serum and tissue element levels and erythrocyte osmotic fragility in rats. A total of 40 male Wistar Albino rats were divided into five groups: control, group I (3 weeks, 8 mg/kg), group II (6 weeks, 8 mg/kg), group III (3 weeks, 16 mg/kg), and group IV (6 weeks, 16 mg/kg). Al chloride (AlCl3) was injected intraperitoneally (i.p.) five times a week. At the end of the experimental period, levels of Al, iron (Fe), copper (Cu), and zinc (Zn) in serum, liver, and kidney tissues were measured using inductively coupled plasma optical emission spectrometry. Osmotic fragility was determined using a spectrophotometer. The results of the experiment indicate that Al induced a statistically significant increase in Al and Fe concentrations in liver and serum as well as in Cu in the kidney. The Fe concentration in serum and kidney tissues was significantly lower in all the groups. As a result of our study, it may be concluded that tissue Al accumulation may lead to an increase in osmotic fragility of erythrocytes and abnormal trace element levels.
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(1)67 differences (15)5 correlations (29)3 influence (44)2 dose-dependent
(2)40 increase (16)5 effects (30)3 negative (45)2 elevation
(3)36 difference (17)5 for (31)3 number (46)2 evidence
(4)28 decrease (18)5 increases (32)3 roles (47)2 factors
(5)12 reduction (19)5 risk (33)2 (P (48)2 group
(6)11 predictors (20)4 effect (35)2 alterations (49)2 inhibition
(7)10 association (21)4 in (36)2 and (50)2 interaction
(8)9 improvement (22)4 reductions (37)2 at (51)2 morbidity
(9)8 *null* (23)4 relationship (38)2 between-group (52)2 positive
(10)7 changes (24)3 (p (39)2 blood (53)2 prediction
(11)7 predictor (25)3 alteration (40)2 challenge (54)2 proportion
(12)7 role (26)3 as (41)2 contribution (55)2 source
(13)6 correlation (27)3 higher (42)2 cytotoxic (56)2 time
(14)5 associations (28)3 improvements (43)2 decreases

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--- WordNet output for significant --- =>意義深い, 重大な, 意味のある, 意味ありげな, 重要な Overview of adj significant The adj significant has 4 senses (first 4 from tagged texts) 1. (18) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 2. (9) significant, substantial -- (fairly large; "won by a substantial margin") 3. (3) significant -- (too closely correlated to be attributed to chance and therefore indicating a systematic relation; "the interaction effect is significant at the .01 level"; "no significant difference was found") 4. (2) meaning, pregnant, significant -- (rich in significance or implication; "a meaning look") --- WordNet end ---