- Cardiac complications of high-dose cytosine arabinoside (HiDAC), although rare, predominantly include pericarditis, pericardial effusion and cardiomyopathy (with concurrent use of cyclophosphamide). Clinically significant arrhythmias associated with HiDAC, although reported in the literature, are rare. The following case report has for the first time used the Naranjo Scale to document a high-probability association (definite adverse drug reaction) of cytarabine with symptomatic sinus bradycardia.
=>意義深い, 重大な, 意味のある, 意味ありげな, 重要な
Overview of adj significant
The adj significant has 4 senses (first 4 from tagged texts)
1. (18) significant, important -- (important in effect or meaning; "a significant change in tax
laws"; "a significant change in the Constitution"; "a significant contribution"; "significant
details"; "statistically significant")
2. (9) significant, substantial -- (fairly large; "won by a substantial margin")
3. (3) significant -- (too closely correlated to be attributed to chance and therefore indicating a
systematic relation; "the interaction effect is significant at the .01 level"; "no significant
difference was found")
4. (2) meaning, pregnant, significant -- (rich in significance or implication; "a meaning look")
--- WordNet end ---