368) This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes. |
PMID:23965335 DOI:10.1177/1076029613501542 |
2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis |
* Evaluation of 2 nomogram-based strategies for dosing argatroban in patients with known or suspected heparin-induced thrombocytopenia. |
- No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study was conducted to evaluate the effectiveness of 2 argatroban nomograms on reaching therapeutic anticoagulation. Patients treated with argatroban were separated into 2 sliding scale groups, percentage adjustments (PAs) and predefined dose increments (PDIs). The primary outcome was the time to reach a therapeutic activated partial thromboplastin time (aPTT). The average initial dose and dose to achieve a therapeutic aPTT were similar between the groups. There was also no difference in the number of dose changes. The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = .015. This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes. |
(1)67 differences | (15)5 correlations | (29)3 influence | (44)2 dose-dependent |
(2)40 increase | (16)5 effects | (30)3 negative | (45)2 elevation |
(3)36 difference | (17)5 for | (31)3 number | (46)2 evidence |
(4)28 decrease | (18)5 increases | (32)3 roles | (47)2 factors |
(5)12 reduction | (19)5 risk | (33)2 (P | (48)2 group |
(6)11 predictors | (20)4 effect | (35)2 alterations | (49)2 inhibition |
(7)10 association | (21)4 in | (36)2 and | (50)2 interaction |
(8)9 improvement | (22)4 reductions | (37)2 at | (51)2 morbidity |
(9)8 *null* | (23)4 relationship | (38)2 between-group | (52)2 positive |
(10)7 changes | (24)3 (p | (39)2 blood | (53)2 prediction |
(11)7 predictor | (25)3 alteration | (40)2 challenge | (54)2 proportion |
(12)7 role | (26)3 as | (41)2 contribution | (55)2 source |
(13)6 correlation | (27)3 higher | (42)2 cytotoxic | (56)2 time |
(14)5 associations | (28)3 improvements | (43)2 decreases |
add keyword