kwic
significant
significant
right
off
ON
345
1
100
500
strict
ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for significant out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to significant]
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 345) Meanwhile, a significant dose-dependent increase was observed in HSI, indicating the activation of hepatic VTG production in 4-NP- and E2-injected fish. |
| PMID:23258736 DOI:10.1177/0748233712469646 |
| 2015 Toxicology and industrial health |
| * Induction of vitellogenin synthesis in immature male yellowfin seabream (Acanthopagrus latus) exposed to 4-nonylphenol and 17β-estradiol. |
| - In the present study, the effects of xenoestrogen 4-nonylphenol (4-NP) and 17β-estradiol (E2) on the synthesis of vitellogenin (VTG) in immature male yellowfin seabream (Acanthoparus latus) were assessed to determine the potential use of this species as a biological model for studying endocrine disrupters in the Musa estuary in southern seawaters of Iran. A total number of 104 fish were injected by 10, 50, 100, 150 and 200 µg g(-) (1) week(-) (1) of 4-NP and 2 µg g(-) (1) week(-) (1) of E2, and their blood plasma was obtained for biochemical analysis on days 0, 7 and 14. The hepatosomatic index (HSI) of each fish was also recorded at each sampling time. The results showed that 4-NP significantly induced VTG synthesis in A. latus, which was detected by gel electrophoresis as two major protein bands (∼210 and 191 KDa). The induction of VTG was also determined indirectly by measuring the alkali-labile phosphate, total plasma calcium and protein. All of these VTG indicators significantly increased in the plasma of 4-NP- and E2-treated fish. Meanwhile, a significant dose-dependent increase was observed in HSI, indicating the activation of hepatic VTG production in 4-NP- and E2-injected fish. Furthermore, the plasma alanine aminotransferase and aspartate aminotransferase concentrations significantly increased in 4-NP-treated fish, presumably reflecting a situation of hepatic tissue damage due to 4-NP toxicity. Based on the results, it is suggested that A. latus could be used successfully as a model species for future studies of endocrine disrupting contaminants in the Musa estuary. |
[
right
kwic]
(1)67  differences |
(15)5 correlations |
(29)3 influence |
(44)2 dose-dependent |
| (2)40 increase |
(16)5 effects |
(30)3 negative |
(45)2 elevation |
| (3)36 difference |
(17)5 for |
(31)3 number |
(46)2 evidence |
| (4)28 decrease |
(18)5 increases |
(32)3 roles |
(47)2 factors |
| (5)12 reduction |
(19)5 risk |
(33)2 (P |
(48)2 group |
| (6)11 predictors |
(20)4 effect |
(35)2 alterations |
(49)2 inhibition |
| (7)10 association |
(21)4 in |
(36)2 and |
(50)2 interaction |
| (8)9 improvement |
(22)4 reductions |
(37)2 at |
(51)2 morbidity |
| (9)8 *null* | (23)4 relationship |
(38)2 between-group |
(52)2 positive |
| (10)7 changes |
(24)3 (p |
(39)2 blood |
(53)2 prediction |
| (11)7 predictor |
(25)3 alteration |
(40)2 challenge |
(54)2 proportion |
| (12)7 role |
(26)3 as |
(41)2 contribution |
(55)2 source |
| (13)6 correlation |
(27)3 higher |
(42)2 cytotoxic |
(56)2 time |
| (14)5 associations |
(28)3 improvements |
(43)2 decreases |
add keyword
--- WordNet output for significant ---