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583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found

324) These results showed that different concentrations of thallium (25-200 µM) induced a significant (P < 0.05) increase in mitochondrial ROS formation, ATP depletion, GSH oxidation, mitochondrial outer membrane rupture, mitochondrial swelling, MMP collapse, and cytochrome c release.

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PMID:23996974 DOI:10.1002/tox.21900

2015 Environmental toxicology

* Toxicity of thallium on isolated rat liver mitochondria: the role of oxidative stress and MPT pore opening.

- Thallium(I) is a highly toxic heavy metal; however, up to now, its mechanisms are poorly understood. The authors' previous studies showed that this compound could induce reactive oxygen species (ROS) formation, reduced glutathione (GSH) oxidation, membrane lipid peroxidation, and mitochondrial membrane potential (MMP) collapse in isolated rat hepatocyte. Because the liver is the storage site of thallium, it seems that the liver mitochondria are one of the important targets for hepatotoxicity. In this investigation, the effects of thallium on mitochondria were studied to investigate its mechanisms of toxicity. Mitochondria were isolated from rat liver and incubated with different concentrations of thallium (25-200 µM). Thallium(I)-treated mitochondria showed a marked elevation in oxidative stress parameters accompanied by MMP collapse when compared with the control group. These results showed that different concentrations of thallium (25-200 µM) induced a significant (P < 0.05) increase in mitochondrial ROS formation, ATP depletion, GSH oxidation, mitochondrial outer membrane rupture, mitochondrial swelling, MMP collapse, and cytochrome c release. In general, these data strongly supported that the thallium(I)-induced liver toxicity is a result of the disruptive effect of this metal on the mitochondrial respiratory complexes (I, II, and IV), which are the obvious causes of metal-induced ROS formation and ATP depletion. The latter two events, in turn, trigger cell death signaling via opening of mitochondrial permeability transition pore and cytochrome c expulsion.

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[frequency of next (right) word to significant]

(1)67 differences	(15)5 correlations	(29)3 influence	(44)2 dose-dependent
(2)40 increase	(16)5 effects	(30)3 negative	(45)2 elevation
(3)36 difference	(17)5 for	(31)3 number	(46)2 evidence
(4)28 decrease	(18)5 increases	(32)3 roles	(47)2 factors
(5)12 reduction	(19)5 risk	(33)2 (P	(48)2 group
(6)11 predictors	(20)4 effect	(35)2 alterations	(49)2 inhibition
(7)10 association	(21)4 in	(36)2 and	(50)2 interaction
(8)9 improvement	(22)4 reductions	(37)2 at	(51)2 morbidity
(9)8 null	(23)4 relationship	(38)2 between-group	(52)2 positive
(10)7 changes	(24)3 (p	(39)2 blood	(53)2 prediction
(11)7 predictor	(25)3 alteration	(40)2 challenge	(54)2 proportion
(12)7 role	(26)3 as	(41)2 contribution	(55)2 source
(13)6 correlation	(27)3 higher	(42)2 cytotoxic	(56)2 time
(14)5 associations	(28)3 improvements	(43)2 decreases

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--- WordNet output for significant --- =>意義深い, 重大な, 意味のある, 意味ありげな, 重要な Overview of adj significant The adj significant has 4 senses (first 4 from tagged texts) 1. (18) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 2. (9) significant, substantial -- (fairly large; "won by a substantial margin") 3. (3) significant -- (too closely correlated to be attributed to chance and therefore indicating a systematic relation; "the interaction effect is significant at the .01 level"; "no significant difference was found") 4. (2) meaning, pregnant, significant -- (rich in significance or implication; "a meaning look") --- WordNet end ---