266) The increase in MPV values was statistically significant for the first 3 days of sepsis in Gram-positive septic patients and for all 5 days in the other groups (p < 0.001). |
PMID:22731700 DOI:10.3109/09537104.2012.701027 |
2015 Platelets |
* Platelet and mean platelet volume kinetics in adult patients with sepsis. |
- The aims of this study were to evaluate the kinetics of platelet counts and mean platelet volume (MPV) in adults with sepsis and to determine whether the responses are infection-specific. This retrospective cohort study included patients admitted to a tertiary-care teaching hospital with microbiologically proven nosocomial sepsis between January 2006 and January 2011. Platelet counts and MPV measurements were examined daily for 5 days after the onset of sepsis. During the study period, 151 of the 214 sepsis episodes were associated with thrombocytopenia. Gram-positive microorganisms were the most frequently isolated. The decrease in platelet counts was statistically significant for the first 3 days of sepsis in Gram-positive septic patients, for 4 days in Gram-negative septic patients and for all 5 days in fungal septic patients (p < 0.001). The increase in MPV values was statistically significant for the first 3 days of sepsis in Gram-positive septic patients and for all 5 days in the other groups (p < 0.001). We conclude that fungal sepsis has a stronger association with thrombocytopenia and increased MPV. |
(1)67 differences | (15)5 correlations | (29)3 influence | (44)2 dose-dependent |
(2)40 increase | (16)5 effects | (30)3 negative | (45)2 elevation |
(3)36 difference | (17)5 for | (31)3 number | (46)2 evidence |
(4)28 decrease | (18)5 increases | (32)3 roles | (47)2 factors |
(5)12 reduction | (19)5 risk | (33)2 (P | (48)2 group |
(6)11 predictors | (20)4 effect | (35)2 alterations | (49)2 inhibition |
(7)10 association | (21)4 in | (36)2 and | (50)2 interaction |
(8)9 improvement | (22)4 reductions | (37)2 at | (51)2 morbidity |
(9)8 *null* | (23)4 relationship | (38)2 between-group | (52)2 positive |
(10)7 changes | (24)3 (p | (39)2 blood | (53)2 prediction |
(11)7 predictor | (25)3 alteration | (40)2 challenge | (54)2 proportion |
(12)7 role | (26)3 as | (41)2 contribution | (55)2 source |
(13)6 correlation | (27)3 higher | (42)2 cytotoxic | (56)2 time |
(14)5 associations | (28)3 improvements | (43)2 decreases |
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