ELIZA

return kwic search for significant out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found

247) The degree of cognitive impairment, as measured by the Mini-Mental Status Examination score, was found to have a significant correlation with the Gal-3 serum levels in all patients and healthy controls.

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PMID:23823143 DOI:10.1177/1533317513495107

2015 American journal of Alzheimer's disease and other dementias

* Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer's Disease.

- Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system. Galectin-3 (Gal-3) is characterized by a conserved sequence within the carbohydrate recognition domain. The effect of Gal-3 in AD is presently unknown. In this study, we found significantly increased Gal-3 serum levels in patients with AD compared to control participants (P=.017). There was no significant difference between patients with mild cognitive impairment (MCI) and healthy controls (P=.143) or between patients with AD and MCI (P=.688). The degree of cognitive impairment, as measured by the Mini-Mental Status Examination score, was found to have a significant correlation with the Gal-3 serum levels in all patients and healthy controls. These data suggest that Gal-3 potentially plays a role in the neuropathogenesis of AD. The Gal-3 found in serum could be a potential candidate for a biomarker panel for AD diagnosis.

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(1)67 differences	(15)5 correlations	(29)3 influence	(44)2 dose-dependent
(2)40 increase	(16)5 effects	(30)3 negative	(45)2 elevation
(3)36 difference	(17)5 for	(31)3 number	(46)2 evidence
(4)28 decrease	(18)5 increases	(32)3 roles	(47)2 factors
(5)12 reduction	(19)5 risk	(33)2 (P	(48)2 group
(6)11 predictors	(20)4 effect	(35)2 alterations	(49)2 inhibition
(7)10 association	(21)4 in	(36)2 and	(50)2 interaction
(8)9 improvement	(22)4 reductions	(37)2 at	(51)2 morbidity
(9)8 null	(23)4 relationship	(38)2 between-group	(52)2 positive
(10)7 changes	(24)3 (p	(39)2 blood	(53)2 prediction
(11)7 predictor	(25)3 alteration	(40)2 challenge	(54)2 proportion
(12)7 role	(26)3 as	(41)2 contribution	(55)2 source
(13)6 correlation	(27)3 higher	(42)2 cytotoxic	(56)2 time
(14)5 associations	(28)3 improvements	(43)2 decreases

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--- WordNet output for significant --- =>意義深い, 重大な, 意味のある, 意味ありげな, 重要な Overview of adj significant The adj significant has 4 senses (first 4 from tagged texts) 1. (18) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 2. (9) significant, substantial -- (fairly large; "won by a substantial margin") 3. (3) significant -- (too closely correlated to be attributed to chance and therefore indicating a systematic relation; "the interaction effect is significant at the .01 level"; "no significant difference was found") 4. (2) meaning, pregnant, significant -- (rich in significance or implication; "a meaning look") --- WordNet end ---