ELIZA

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583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found

183) Inhibition experiments for the IP3/Ca2+ signalling pathway showed either a complete inhibition or a significant reduction of the vitellogenic process.

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PMID:23890344 DOI:10.1017/S0967199413000324

2015 Zygote (Cambridge, England)

* Xepac protein and IP3/Ca2+ pathway implication during Xenopus laevis vitellogenesis.

- The objective of this study was to elucidate the signalling pathways initiated by cAMP once inside the Xenopus laevis oocyte, where it triggers and maintains vitellogenin endocytic uptake. Our results showed the presence of Xepac transcripts at all stages of oogenesis and we demonstrated that a cAMP analogue that exclusively activates Xepac, 8-CPT, was able to rescue the endocytic activity in oocytes with uncoupled gap junctions. Inhibition experiments for the IP3/Ca2+ signalling pathway showed either a complete inhibition or a significant reduction of the vitellogenic process. These results were confirmed with the rescue capability of the A-23187 ionophore in those oocyte batches in which the IP3/Ca2+ pathway was inhibited. Taking our findings into account, we propose that the cAMP molecule binds Xepac protein enabling it to activate the IP3/Ca2+ pathway, which is necessary to start and maintain X. laevis vitellogenin uptake.

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(1)67 differences	(15)5 correlations	(29)3 influence	(44)2 dose-dependent
(2)40 increase	(16)5 effects	(30)3 negative	(45)2 elevation
(3)36 difference	(17)5 for	(31)3 number	(46)2 evidence
(4)28 decrease	(18)5 increases	(32)3 roles	(47)2 factors
(5)12 reduction	(19)5 risk	(33)2 (P	(48)2 group
(6)11 predictors	(20)4 effect	(35)2 alterations	(49)2 inhibition
(7)10 association	(21)4 in	(36)2 and	(50)2 interaction
(8)9 improvement	(22)4 reductions	(37)2 at	(51)2 morbidity
(9)8 null	(23)4 relationship	(38)2 between-group	(52)2 positive
(10)7 changes	(24)3 (p	(39)2 blood	(53)2 prediction
(11)7 predictor	(25)3 alteration	(40)2 challenge	(54)2 proportion
(12)7 role	(26)3 as	(41)2 contribution	(55)2 source
(13)6 correlation	(27)3 higher	(42)2 cytotoxic	(56)2 time
(14)5 associations	(28)3 improvements	(43)2 decreases

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--- WordNet output for significant --- =>意義深い, 重大な, 意味のある, 意味ありげな, 重要な Overview of adj significant The adj significant has 4 senses (first 4 from tagged texts) 1. (18) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 2. (9) significant, substantial -- (fairly large; "won by a substantial margin") 3. (3) significant -- (too closely correlated to be attributed to chance and therefore indicating a systematic relation; "the interaction effect is significant at the .01 level"; "no significant difference was found") 4. (2) meaning, pregnant, significant -- (rich in significance or implication; "a meaning look") --- WordNet end ---