ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for significant out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found
180) One-way analysis of variance revealed that the acute and sublethal exposure to the herbicide as well as the experimental periods caused significant reduction in the concentrations of catecholamines (dopamine (DA) and norepinephrine (NE)), elevation of acetylcholine (ACh), and was associated with a marked decrease in the activity of acetylcholinesterase (AChE).
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PMID:23681548 DOI:10.1177/0748233713487248
2015 Toxicology and industrial health
* Bioaccumulation and neurotoxicity of dithiopyridine herbicide in the brain of freshwater fish, Cyprinus carpio.
- The freshwater carp, Cyprinus carpio, was exposed to 0.5 mg (30% of median lethal concentration (LC50)), 1.0 mg (60% of LC50), and 1.6 mg (LC50) of dithiopyridine herbicide per liter for acute (24 h) and 1/10 of LC50 (0.2 mg/L/day) for sublethal (1, 3, 7, 14, and 21 days) experiments. The herbicide bioaccumulation was significantly affected by the acute exposure levels and the experimental periods and was positively correlated with them. One-way analysis of variance revealed that the acute and sublethal exposure to the herbicide as well as the experimental periods caused significant reduction in the concentrations of catecholamines (dopamine (DA) and norepinephrine (NE)), elevation of acetylcholine (ACh), and was associated with a marked decrease in the activity of acetylcholinesterase (AChE). In comparison with the corresponding controls, most levels of the DA and NE and the activity of AChE were significantly decreased, whereas the concentration of ACh was markedly elevated, during acute and sublethal exposure. In the acute and sublethal experiments, the herbicide accumulated in the brain was inversely proportional to the levels of DA and NE and the activity of AChE but has a direct correlation with the concentration of ACh. In addition, the brain's AChE activity was negatively correlated with ACh content during the acute (r = -0.94) and sublethal (r = -0.78) experiments.
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(1)67 differences (15)5 correlations (29)3 influence (44)2 dose-dependent
(2)40 increase (16)5 effects (30)3 negative (45)2 elevation
(3)36 difference (17)5 for (31)3 number (46)2 evidence
(4)28 decrease (18)5 increases (32)3 roles (47)2 factors
(5)12 reduction (19)5 risk (33)2 (P (48)2 group
(6)11 predictors (20)4 effect (35)2 alterations (49)2 inhibition
(7)10 association (21)4 in (36)2 and (50)2 interaction
(8)9 improvement (22)4 reductions (37)2 at (51)2 morbidity
(9)8 *null* (23)4 relationship (38)2 between-group (52)2 positive
(10)7 changes (24)3 (p (39)2 blood (53)2 prediction
(11)7 predictor (25)3 alteration (40)2 challenge (54)2 proportion
(12)7 role (26)3 as (41)2 contribution (55)2 source
(13)6 correlation (27)3 higher (42)2 cytotoxic (56)2 time
(14)5 associations (28)3 improvements (43)2 decreases

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--- WordNet output for significant --- =>意義深い, 重大な, 意味のある, 意味ありげな, 重要な Overview of adj significant The adj significant has 4 senses (first 4 from tagged texts) 1. (18) significant, important -- (important in effect or meaning; "a significant change in tax laws"; "a significant change in the Constitution"; "a significant contribution"; "significant details"; "statistically significant") 2. (9) significant, substantial -- (fairly large; "won by a substantial margin") 3. (3) significant -- (too closely correlated to be attributed to chance and therefore indicating a systematic relation; "the interaction effect is significant at the .01 level"; "no significant difference was found") 4. (2) meaning, pregnant, significant -- (rich in significance or implication; "a meaning look") --- WordNet end ---