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583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found
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583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 178) In the CA test, there was concentration-dependent significant reduction in mitotic index and induction of different types of CAs. |
| PMID:23545846 DOI:10.1177/0748233713483206 |
| 2015 Toxicology and industrial health |
| * Determination of the mutagenic and genotoxic potential of simulated leachate from an automobile workshop soil on eukaryotic system. |
| - Contamination of soil and water bodies with spent engine oil and petroleum products is a serious ecological problem, primarily in the automobile workshops and garages. This has potential short and chronic adverse health risks. Information is currently scarce on the potential mutagenicity and genotoxicity of such wastes. In this study, the potential mutagenic and genotoxic effects of simulated leachate from automobile workshop soil in Sagamu, Ogun state, Nigeria, were investigated. The assays utilized were bone marrow micronucleus (MN) and chromosome aberration (CA), sperm morphology and sperm count in mice. The physicochemical analysis of the leachate was also carried out. Experiments were carried out at concentrations of 1, 5, 10, 25, 50, 75 and 100% (volume per volume; leachate:distilled water) of the leachate sample. MN analysis showed a concentration-dependent induction of micronucleated polychromatic erythrocytes across the treatment groups. In the CA test, there was concentration-dependent significant reduction in mitotic index and induction of different types of CAs. Assessment of sperm shape showed a significant increase in sperm abnormalities with significant decrease in mean sperm count in treated groups. Heavy metals analyzed in the tested sample are believed to contribute significantly to the observed genetic damage. This indicates that automobile workshop soil-simulated leachate contains potential genotoxic agents and constitutes a genetic risk in exposed human population. |
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