ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for showed out of >500 occurrences
663834 occurrences (No.9 in the rank) during 5 years in the PubMed. [no cache]
500 found
26) In vitro studies showed that RARα was able to bind to and transactivate the TrkB promoter via a putative RA response element within the TrkB promoter.
* Abnormal retinoid and TrkB signaling in the prefrontal cortex in mood disorders.
- The prefrontal cortex shows structural and functional alterations in mood disorders. Retinoid signaling, brain-derived neurotrophic factor (BDNF), and its receptor TrkB are reported to be involved in depression. Here, we found that mRNA levels of key elements of retinoid signaling were significantly reduced in the postmortem dorsolateral prefrontal cortex/anterior cingulate cortex (ACC) from elderly depressed patients who did not die from suicide. Decreased mRNA levels of BDNF and TrkB isoforms were also found. Similar alterations were observed in rats subjected to chronic unpredictable mild stress. Along with neurons immunopositive for both retinoic acid receptor-α (RARα) and TrkB, a positive correlation between mRNA levels of the 2 receptors was found in the ACC of control subjects but not of depressed patients. In vitro studies showed that RARα was able to bind to and transactivate the TrkB promoter via a putative RA response element within the TrkB promoter. In conclusion, the retinoid and BDNF-TrkB signaling in the prefrontal cortex are compromised in mood disorders, and the transcriptional upregulation of TrkB by RARα provide a possible mechanism for their interaction. The retinoid signaling pathway that may activate TrkB expression will be an alternative novel target for BDNF-based antidepressant treatment.
Overview of verb show
The verb show has 12 senses (first 11 from tagged texts)
1. (136) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested
audience; "She shows her dogs frequently"; "We will demo the new software in Washington")
2. (63) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an
example, explanation or experiment; "The experiment demonstrated the instability of the compound";
"The mathematician showed the validity of the conjecture")
3. (57) testify, bear witness, prove, evidence, show -- (provide evidence for; "The blood test
showed that he was the father"; "Her behavior testified to her incompetence")
4. (43) show -- (make visible or noticeable; "She showed her talent for cooking"; "Show me your
etchings, please")
5. (32) picture, depict, render, show -- (show in, or as in, a picture; "This scene depicts country
life"; "the face of the child is rendered with much tenderness in this painting")
6. (24) express, show, evince -- (give expression to; "She showed her disappointment")
7. (24) indicate, point, designate, show -- (indicate a place, direction, person, or thing; either
spatially or figuratively; "I showed the customer the glove section"; "He pointed to the empty
parking space"; "he indicated his opponents")
8. (11) show, show up -- (be or become visible or noticeable; "His good upbringing really shows";
"The dirty side will show")
9. (7) read, register, show, record -- (indicate a certain reading; of gauges and instruments; "The
thermometer showed thirteen degrees below zero"; "The gauge read `empty'")
10. (6) show -- (give evidence of, as of records; "The diary shows his distress that evening")
11. (2) usher, show -- (take (someone) to their seats, as in theaters or auditoriums; "The usher
showed us to our seats")
12. show -- (finish third or better in a horse or dog race; "he bet $2 on number six to show")
--- WordNet end ---