ELIZA

return kwic search for show out of >500 occurrences
663834 occurrences (No.9 in the rank) during 5 years in the PubMed. [no cache] 500 found

15) Taken together, the results show that EphA2 endows invasiveness of GSCs in vivo in cooperation with Akt and regulates glioma stem cell properties.

--- ABSTRACT ---

PMID:24488013 DOI:10.1038/onc.2013.590

2015 Oncogene

* EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.

- Diffuse infiltrative invasion is a major cause for the dismal prognosis of glioblastoma multiforme (GBM), but the underlying mechanisms remain incompletely understood. Using human glioma stem cells (GSCs) that recapitulate the invasive propensity of primary GBM, we find that EphA2 critically regulates GBM invasion in vivo. EphA2 was expressed in all seven GSC lines examined, and overexpression of EphA2 enhanced intracranial invasion. The effects required Akt-mediated phosphorylation of EphA2 on serine 897. In vitro the Akt-EphA2 signaling axis is maintained in the absence of ephrin-A ligands and is disrupted upon ligand stimulation. To test whether ephrin-As in tumor microenvironment can regulate GSC invasion, the newly established Efna1;Efna3;Efna4 triple knockout mice (TKO) were used in an ex vivo brain slice invasion assay. We observed significantly increased GSC invasion through the brain slices of TKO mice relative to wild-type (WT) littermates. Mechanistically EphA2 knockdown suppressed stem cell properties of GSCs, causing diminished self-renewal, reduced stem marker expression and decreased tumorigenicity. In a subset of GSCs, the reduced stem cell properties were associated with lower Sox2 expression. Overexpression of EphA2 promoted stem cell properties in a kinase-independent manner and increased Sox2 expression. Disruption of Akt-EphA2 cross-talk attenuated stem cell marker expression and neurosphere formation while having minimal effects on tumorigenesis. Taken together, the results show that EphA2 endows invasiveness of GSCs in vivo in cooperation with Akt and regulates glioma stem cell properties.

--- ABSTRACT END ---

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(1)255 that	(9)5 here	(17)3 different	(25)2 differences
(2)30 a	(10)5 promise	(18)3 risk	(26)2 differential
(3)24 the	(11)4 by	(19)3 statistically	(27)2 for
(4)13 how	(12)4 greater	(20)3 such	(28)2 great
(5)13 significant	(13)4 higher	(21)2 null	(29)2 important
(6)8 any	(14)4 increased	(22)2 beneficial	(30)2 lower
(7)8 that,	(15)4 more	(23)2 changes
(8)7 an	(16)4 similar	(24)2 clinical

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--- WordNet output for show --- =>教える, 見せること, 展覧会, 見世物, 外観, を見せる, を案内する, を明らかにする, 見える Overview of noun show The noun show has 4 senses (first 2 from tagged texts) 1. (18) show -- (the act of publicly exhibiting or entertaining; "a remarkable show of skill") 2. (9) display, show -- (something intended to communicate a particular impression; "made a display of strength"; "a show of impatience"; "a good show of looking interested") 3. show -- (a social event involving a public performance or entertainment; "they wanted to see some of the shows on Broadway") 4. appearance, show -- (pretending that something is the case in order to make a good impression; "they try to keep up appearances"; "that ceremony is just for show") Overview of verb show The verb show has 12 senses (first 11 from tagged texts) 1. (136) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested audience; "She shows her dogs frequently"; "We will demo the new software in Washington") 2. (63) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an example, explanation or experiment; "The experiment demonstrated the instability of the compound"; "The mathematician showed the validity of the conjecture") 3. (57) testify, bear witness, prove, evidence, show -- (provide evidence for; "The blood test showed that he was the father"; "Her behavior testified to her incompetence") 4. (43) show -- (make visible or noticeable; "She showed her talent for cooking"; "Show me your etchings, please") 5. (32) picture, depict, render, show -- (show in, or as in, a picture; "This scene depicts country life"; "the face of the child is rendered with much tenderness in this painting") 6. (24) express, show, evince -- (give expression to; "She showed her disappointment") 7. (24) indicate, point, designate, show -- (indicate a place, direction, person, or thing; either spatially or figuratively; "I showed the customer the glove section"; "He pointed to the empty parking space"; "he indicated his opponents") 8. (11) show, show up -- (be or become visible or noticeable; "His good upbringing really shows"; "The dirty side will show") 9. (7) read, register, show, record -- (indicate a certain reading; of gauges and instruments; "The thermometer showed thirteen degrees below zero"; "The gauge read `empty'") 10. (6) show -- (give evidence of, as of records; "The diary shows his distress that evening") 11. (2) usher, show -- (take (someone) to their seats, as in theaters or auditoriums; "The usher showed us to our seats") 12. show -- (finish third or better in a horse or dog race; "he bet $2 on number six to show") --- WordNet end ---