* Role of inflammatory cells and toll-like receptors in atherosclerosis.
- The primary cause of cerebrovascular disease is atherosclerosis, to which many factors contribute. At first many saw atherosclerosis as a lipid-driven disease. Recently inflammation has appeared as a significant factor in the disease. Innate immune cells, for example monocytes and macrophages, are important in atherosclerosis. Toll-like receptors (TLRs) are the best-studied family of receptor in the immune system. TLR engagement with their ligands stimulates pro-inflammatory cytokine production and foam cell generation. Recently certain TLRs have shown a protective role in atherosclerosis. In this review, we analyse innate immunity, focusing on TLR signalling and macrophages, in atherosclerosis and acute cerebrovascular complications, and thereby discuss their potential as therapeutic targets.
=>役目, 役割, 任務, 職務, 役
Overview of noun role
The noun role has 4 senses (first 4 from tagged texts)
1. (34) function, office, part, role -- (the actions and activities assigned to or required or
expected of a person or group; "the function of a teacher"; "the government must do its part"; "play
its role")
2. (10) character, role, theatrical role, part, persona -- (an actor's portrayal of someone in a
play; "she played the part of Desdemona")
3. (8) function, purpose, role, use -- (what something is used for; "the function of an auger is to
bore holes"; "ballet is beautiful but what use is it?")
4. (6) role -- (normal or customary activity of a person in a particular social setting; "what is
your role on the team?")
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