ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for revealed out of >500 occurrences
324965 occurrences (No.62 in the rank) during 5 years in the PubMed. [no cache] 500 found
24) Ultrastructural analysis revealed that NE-labeled axon terminals form synapses with CRF- and DYN-containing neurons in the CeA.
--- ABSTRACT ---
PMID:24271021 DOI:10.1007/s00429-013-0674-8
2015 Brain structure & function
* Direct targeting of peptidergic amygdalar neurons by noradrenergic afferents: linking stress-integrative circuitry.
- Amygdalar norepinephrine (NE) plays a key role in regulating neural responses to emotionally arousing stimuli and is involved in memory consolidation of emotionally charged events. Corticotropin-releasing factor (CRF) and dynorphin (DYN), two neuropeptides that mediate the physiological and behavioral responses to stress, are abundant in the central nucleus of the amygdala (CeA), and directly innervate brainstem noradrenergic locus coeruleus (LC) neurons. Whether the CRF- and DYN-containing amygdalar neurons receive direct noradrenergic innervation has not yet been elucidated. The present study sought to define cellular substrates underlying noradrenergic modulation of CRF- and DYN-containing neurons in the CeA using immunohistochemistry and electron microscopy. Ultrastructural analysis revealed that NE-labeled axon terminals form synapses with CRF- and DYN-containing neurons in the CeA. Semi-quantitative analysis showed that approximately 31 % of NET-labeled axon terminals targeted CeA neurons that co-expressed DYN and CRF. As a major source of CRF innervation to the LC, it is also not known whether CRF-containing CeA neurons are directly targeted by noradrenergic afferents. To test this, retrograde tract tracing using FluoroGold from the LC was combined with immunocytochemical detection of CRF and NET in the CeA. Our results revealed a population of LC-projecting CRF-containing CeA neurons that are directly innervated by NE afferents. Analysis showed that approximately 34 % of NET-labeled axon terminals targeted LC-projecting CeA neurons that contain CRF. Taken together, these results indicate significant interactions between NE, CRF and DYN in this critical limbic region and reveal direct synaptic interactions of NE with amygdalar CRF that influence the LC-NE arousal system.
--- ABSTRACT END ---
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(1)193 that (9)4 five (17)2 common (25)2 new
(2)61 a (10)4 high (18)2 distinct (26)2 numerous
(3)21 the (11)3 statistically (19)2 enhanced (27)2 right
(4)14 no (12)3 that, (20)2 evidence (28)2 severe
(5)13 an (13)3 three (21)2 four (29)2 significantly
(6)13 significant (14)3 two (22)2 higher
(7)7 by (15)2 *null* (23)2 in
(8)5 multiple (16)2 as (24)2 moderate

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--- WordNet output for revealed --- Overview of verb reveal The verb reveal has 3 senses (first 2 from tagged texts) 1. (34) uncover, bring out, unveil, reveal -- (make visible; "Summer brings out bright clothes"; "He brings out the best in her") 2. (17) unwrap, disclose, let on, bring out, reveal, discover, expose, divulge, break, give away, let out -- (make known to the public information that was previously known only to a few people or that was meant to be kept a secret; "The auction house would not disclose the price at which the van Gogh had sold"; "The actress won't reveal how old she is"; "bring out the truth"; "he broke the news to her"; "unwrap the evidence in the murder case") 3. reveal -- (disclose directly or through prophets; "God rarely reveal his plans for Mankind") --- WordNet end ---