2015 Journal of tissue engineering and regenerative medicine
* Fate of modular cardiac tissue constructs in a syngeneic rat model.
- Modular cardiac tissues developed both vascular and cardiac structures in vivo, provided that the host response was attenuated by omitting xenoproteins from the modules. Collagen gel modules (with Matrigel(TM)) containing cardiomyocytes (CMs) alone or CMs with surface-seeded endothelial cells (ECs; CM/EC modules) were injected into the peri-infarct zone of the heart in syngeneic Lewis rats. After 3 weeks, donor ECs developed into blood vessel-like structures that also contained erythrocytes. However, no donor CMs were found within the implant sites, presumably because host cells including macrophages and T cells infiltrated extensively into the injection sites. To lessen the host response, Matrigel was omitted from the matrix and the modules were rinsed with serum-free medium prior to implantation. Host cell infiltration was attenuated, resulting in a higher degree of vascularization with CM/EC modules than with CM modules without ECs. Most importantly, donor CMs matured into striated muscle-like structures in Matrigel-free implants.
=>反応, 応答, 返答, 返報, 反響, 答唱句
Overview of noun response
The noun response has 7 senses (first 5 from tagged texts)
1. (11) response -- (a result; "this situation developed in response to events in Africa")
2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent
stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age")
3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a
question or request or criticism or accusation; "I waited several days for his answer"; "he wrote
replies to several of his critics")
4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the
cold reception she received from her superiors")
5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest
or minister)
6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his
reply")
7. response -- (the manner in which an electrical or mechanical device responds to an input signal
or a range of input signals)
--- WordNet end ---