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return kwic search for response out of >500 occurrences
343831 occurrences (No.54 in the rank) during 5 years in the PubMed. [no cache] 500 found

404) The potency of ARV agents in AIDS clinical trials can be assessed on the basis of a viral response such as viral decay rate or viral load change in plasma.

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PMID:22045781 DOI:10.1177/0962280211426184

2015 Statistical methods in medical research

* Piecewise mixed-effects models with skew distributions for evaluating viral load changes: A Bayesian approach.

- Studies of human immunodeficiency virus dynamics in acquired immuno deficiency syndrome (AIDS) research are very important in evaluating the effectiveness of antiretroviral (ARV) therapies. The potency of ARV agents in AIDS clinical trials can be assessed on the basis of a viral response such as viral decay rate or viral load change in plasma. Following ARV treatment, the profile of each subject's viral load tends to follow a 'broken stick'-like dynamic trajectory, indicating multiple phases of decline and increase in viral loads. Such multiple-phases (change-points) can be described by a random change-point model with random subject-specific parameters. One usually assumes a normal distribution for model error. However, this assumption may be unrealistic, obscuring important features of within- and among-subject variations. In this article, we propose piecewise linear mixed-effects models with skew-elliptical distributions to describe the time trend of a response variable under a Bayesian framework. This methodology can be widely applied to real problems for longitudinal studies. A real data analysis, using viral load data from an AIDS study, is carried out to illustrate the proposed method by comparing various candidate models. Biologically important findings are reported, and these findings also suggest that it is very important to assume a model with skew distribution in order to achieve reliable results, in particular, when the data exhibit skewness.

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[frequency of next (right) word to response]

(1)146 to	(14)4 proteins	(27)3 time	(40)2 following
(2)32 null	(15)4 rates	(28)3 times	(41)2 from
(3)31 and	(16)4 that	(29)3 which	(42)2 including
(4)22 of	(17)4 the	(30)2 (ABR)	(43)2 latency
(5)21 rate	(18)3 at	(31)2 (DDR)	(44)2 mediated
(6)14 was	(19)3 during	(32)2 (UPR)	(45)2 or
(7)13 in	(20)3 elements	(33)2 after	(46)2 rate)
(8)8 selection	(21)3 models	(34)2 are	(47)2 rates,
(9)7 surface	(22)3 options	(35)2 boundaries	(48)2 such
(10)6 data	(23)3 properties	(36)2 delays	(49)2 theory
(11)6 is	(24)3 strategies	(37)2 effects	(50)2 validity
(12)4 for	(25)3 style	(38)2 element	(51)2 were
(13)4 patterns	(26)3 suppression	(39)2 evaluation

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--- WordNet output for response --- =>反応, 応答, 返答, 返報, 反響, 答唱句 Overview of noun response The noun response has 7 senses (first 5 from tagged texts) 1. (11) response -- (a result; "this situation developed in response to events in Africa") 2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age") 3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation; "I waited several days for his answer"; "he wrote replies to several of his critics") 4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the cold reception she received from her superiors") 5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest or minister) 6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his reply") 7. response -- (the manner in which an electrical or mechanical device responds to an input signal or a range of input signals) --- WordNet end ---