ELIZA

return kwic search for response out of >500 occurrences
343831 occurrences (No.54 in the rank) during 5 years in the PubMed. [no cache] 500 found

291) The aim of this study is to prepare an optimized surface active modified polysaccharide gel of oleoyl alginate using response surface methodology as well as to study its potential use in drug skin delivery as a safe alternative to skin penetration enhancers.

--- ABSTRACT ---

PMID:24266691 DOI:10.3109/10837450.2013.860548

2015 Pharmaceutical development and technology

* Quality by design approach to prepare oleoyl alginate derivative and its use in transdermal delivery.

- The aim of this study is to prepare an optimized surface active modified polysaccharide gel of oleoyl alginate using response surface methodology as well as to study its potential use in drug skin delivery as a safe alternative to skin penetration enhancers. An optimized oleoyl alginate material was obtained using response surface methodology in terms of three different responses, i.e. degree of substitution, viscosity and surface tension. The resultant optimized oleoyl alginates were further studied concerning particle size, surface roughness and particle aggregation concentration measurements. Franz diffusion cell method was used to monitor skin permeation of ibuprofen lysinate over 6-h period exposure to excised rabbit skin. The optimized oleoyl alginate based on surface tension showed the highest particle size, the lowest surface tension among other preparations and it has also been used as skin penetration enhancer for ibuprofen lysinate. In this study, a polysaccharide derivative was prepared that enhanced skin penetration ability of the model drug i.e. ibuprofen lysinate.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to response]

(1)146 to	(14)4 proteins	(27)3 time	(40)2 following
(2)32 null	(15)4 rates	(28)3 times	(41)2 from
(3)31 and	(16)4 that	(29)3 which	(42)2 including
(4)22 of	(17)4 the	(30)2 (ABR)	(43)2 latency
(5)21 rate	(18)3 at	(31)2 (DDR)	(44)2 mediated
(6)14 was	(19)3 during	(32)2 (UPR)	(45)2 or
(7)13 in	(20)3 elements	(33)2 after	(46)2 rate)
(8)8 selection	(21)3 models	(34)2 are	(47)2 rates,
(9)7 surface	(22)3 options	(35)2 boundaries	(48)2 such
(10)6 data	(23)3 properties	(36)2 delays	(49)2 theory
(11)6 is	(24)3 strategies	(37)2 effects	(50)2 validity
(12)4 for	(25)3 style	(38)2 element	(51)2 were
(13)4 patterns	(26)3 suppression	(39)2 evaluation

add keyword

--- WordNet output for response --- =>反応, 応答, 返答, 返報, 反響, 答唱句 Overview of noun response The noun response has 7 senses (first 5 from tagged texts) 1. (11) response -- (a result; "this situation developed in response to events in Africa") 2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age") 3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation; "I waited several days for his answer"; "he wrote replies to several of his critics") 4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the cold reception she received from her superiors") 5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest or minister) 6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his reply") 7. response -- (the manner in which an electrical or mechanical device responds to an input signal or a range of input signals) --- WordNet end ---