ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for research out of >500 occurrences
280501 occurrences (No.89 in the rank) during 5 years in the PubMed. [no cache] 500 found
33) These findings will assist to understand the mechanism of inhibition of SAP-1 for different proteases and provide intimation for further research.
--- ABSTRACT ---
PMID:24261636 DOI:10.1080/07391102.2013.855882
2015 Journal of biomolecular structure & dynamics
* Studies on the interactions of SAP-1 (an N-terminal truncated form of cystatin S) with its binding partners by CD-spectroscopic and molecular docking methods.
- SAP-1 is a 113 amino acid long single-chain protein which belongs to the type 2 cystatin gene family. In our previous study, we have purified SAP-1 from human seminal plasma and observed its cross-class inhibitory property. At this time, we report the interaction of SAP-1 with diverse proteases and its binding partners by CD-spectroscopic and molecular docking methods. The circular dichroism (CD) spectroscopic studies demonstrate that the conformation of SAP-1 is changed after its complexation with proteases, and the alterations in protein secondary structure are quantitatively calculated with increase of α-helices and reduction of β-strand content. To get insight into the interactions between SAP-1 and proteases, we make an effort to model the three-dimensional structure of SAP-1 by molecular modeling and verify its stability and viability through molecular dynamics simulations and finally complexed with different proteases using ClusPro 2.0 Server. A high degree of shape complementarity is examined within the complexes, stabilized by a number of hydrogen bonds (HBs) and hydrophobic interactions. Using HB analyses in different protein complexes, we have identified a series of key residues that may be involved in the interactions between SAP-1 and proteases. These findings will assist to understand the mechanism of inhibition of SAP-1 for different proteases and provide intimation for further research.
--- ABSTRACT END ---
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(1)42 *null* (14)7 that (27)3 as (40)2 from
(2)40 on (15)6 by (28)3 directions (41)2 involving
(3)36 is (16)6 to (29)3 evidence (42)2 participants,
(4)27 and (17)5 projects (30)3 have (43)2 progress
(5)25 has (18)4 culture (31)3 method (44)2 sponsored
(6)14 in (19)4 design (32)3 results (45)2 the
(7)12 was (20)4 findings (33)3 shows (46)2 topic
(8)11 are (21)4 needs (34)3 study (47)2 towards
(9)11 should (22)4 project (35)3 will (48)2 trends
(10)9 into (23)4 questions (36)2 efforts (49)2 using
(11)9 with (24)4 regarding (37)2 examined (50)2 we
(12)8 studies (25)3 & (38)2 focus (51)2 work
(13)8 suggests (26)3 aimed (39)2 for

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--- WordNet output for research --- =>調査する, 研究(する), 探求, 調査, 捜索, 研究する Overview of noun research The noun research has 2 senses (first 2 from tagged texts) 1. (46) research -- (systematic investigation to establish facts) 2. (6) inquiry, enquiry, research -- (a search for knowledge; "their pottery deserves more research than it has received") Overview of verb research The verb research has 2 senses (first 1 from tagged texts) 1. (1) research -- (attempt to find out in a systematically and scientific manner; "The student researched the history of that word") 2. research, search, explore -- (inquire into; "the students had to research the history of the Second World War for their history project"; "He searched for information on his relatives on the web"; "Scientists are exploring the nature of consciousness") --- WordNet end ---