ELIZA

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273413 occurrences (No.92 in the rank) during 5 years in the PubMed. [no cache] 500 found

3) We also observed changes in TH mRNA expression in the VTA that could be related to Ago2-induced translational repression of TH mRNA during morphine withdrawal.

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PMID:23927484 DOI:10.1111/adb.12083

2015 Addiction biology

* Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons.

- Epigenetic changes such as microRNAs (miRs)/Ago2-induced gene silencing represent complex molecular signature that regulate cellular plasticity. Recent studies showed involvement of miRs and Ago2 in drug addiction. In this study, we show that changes in gene expression induced by morphine and morphine withdrawal occur with concomitant epigenetic modifications in the mesolimbic dopaminergic (DA) pathway [ventral tegmental area (VTA)/nucleus accumbens (NAc) shell], which is critically involved in drug-induced dependence. We found that acute or chronic morphine administration as well as morphine withdrawal did not modify miR-133b messenger RNA (mRNA) expression in the VTA, whereas Ago2 protein levels were decreased and increased in morphine-dependent rats and after morphine withdrawal, respectively. These changes were paralleled with enhanced and decreased NAc tyrosine hydroxylase (TH) protein (an early DA marker) in morphine-dependent rats and after withdrawal, respectively. We also observed changes in TH mRNA expression in the VTA that could be related to Ago2-induced translational repression of TH mRNA during morphine withdrawal. However, the VTA number of TH-positive neurons suffered no alterations after the different treatment. Acute morphine administration produced a marked increase in TH activity and DA turnover in the NAc (shell). In contrast, precipitated morphine withdrawal decreased TH activation and did not change DA turnover. These findings provide new information into the possible correlation between Ago2/miRs complex regulation and DA neurons plasticity during opiate addiction.

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(1)212 to	(11)4 and	(21)3 changes	(31)2 characteristics
(2)11 quality	(12)4 cognitions	(22)3 death	(32)2 genes,
(3)7 factors	(13)4 deaths	(23)3 disease	(33)2 head
(4)6 complications	(14)4 events	(24)3 functional	(34)2 hospital
(5)6 genes	(15)4 issues	(25)3 stress	(35)2 increases
(6)5 health	(16)4 macular	(26)3 symptoms	(36)2 parameters
(7)5 information	(17)4 osteonecrosis	(27)2 Anxiety	(37)2 proteins
(8)5 injuries	(18)4 with	(28)2 Cognitions	(38)2 psychosocial
(9)5 potentials	(19)3 activity	(29)2 barriers	(39)2 species
(10)4 activities	(20)3 cases	(30)2 brain

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--- WordNet output for related --- =>1.関係のある, 関連した, 2.同族の, 親類関係にある Overview of verb relate The verb relate has 5 senses (first 5 from tagged texts) 1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your earlier comments") 3. (7) relate -- (give an account of; "The witness related the events") 4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?") 5. (2) relate -- (have or establish a relationship to; "She relates well to her peers") Overview of adj related The adj related has 2 senses (first 2 from tagged texts) 1. (20) related, related to -- (being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces") 2. (4) related -- (connected by kinship, common origin, or marriage) --- WordNet end ---