ELIZA

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273413 occurrences (No.92 in the rank) during 5 years in the PubMed. [no cache] 500 found

298) Notably, Akt exerts its anti-apoptotic effects through the phosphorylation of numerous substrates related with cell cycle, genome stability, and cancer development.

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PMID:24038446 DOI:10.1002/mc.22075

2015 Molecular carcinogenesis

* Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells.

- The Akt, family of serine/threonine protein kinases functions as key regulators of multiple aspects of cell behavior, such as survival, proliferation, migration, and carcinogenesis. Notably, Akt exerts its anti-apoptotic effects through the phosphorylation of numerous substrates related with cell cycle, genome stability, and cancer development. In this report, nevertheless, we focused our view on the novel role of Akt which involves in a pro-apoptotic action by phosphorylating second mitochondria derived activator of caspases (Smac) protein during etoposide-induced apoptotic processes. Our data reveals that Akt could bind to and phosphorylate Smac at serine residue 67, which enhances the ability of Smac to interact with the cytosolic X-chromosome linked IAP (XIAP) protein. The cellular interaction of wild-type Smac with XIAP was enhanced with similar activation kinetics of Akt activity, while this interaction was markedly attenuated in cells expressing the phosphorylation-defective mutant S67A-Smac during etoposide-induced apoptosis. Moreover, we provide the evidence indicating that the phosphorylation of Smac at ser-67 markedly upregulates the caspase-3 activity by promoting the interaction of Smac with XIAP. Taken together, we propose that the phosphorylation of Smac by Akt might be a novel mechanism that involves in amplification of caspase cascade pathway during etoposide-induced apoptosis in HeLa cells.

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(1)212 to	(11)4 and	(21)3 changes	(31)2 characteristics
(2)11 quality	(12)4 cognitions	(22)3 death	(32)2 genes,
(3)7 factors	(13)4 deaths	(23)3 disease	(33)2 head
(4)6 complications	(14)4 events	(24)3 functional	(34)2 hospital
(5)6 genes	(15)4 issues	(25)3 stress	(35)2 increases
(6)5 health	(16)4 macular	(26)3 symptoms	(36)2 parameters
(7)5 information	(17)4 osteonecrosis	(27)2 Anxiety	(37)2 proteins
(8)5 injuries	(18)4 with	(28)2 Cognitions	(38)2 psychosocial
(9)5 potentials	(19)3 activity	(29)2 barriers	(39)2 species
(10)4 activities	(20)3 cases	(30)2 brain

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--- WordNet output for related --- =>1.関係のある, 関連した, 2.同族の, 親類関係にある Overview of verb relate The verb relate has 5 senses (first 5 from tagged texts) 1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your earlier comments") 3. (7) relate -- (give an account of; "The witness related the events") 4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?") 5. (2) relate -- (have or establish a relationship to; "She relates well to her peers") Overview of adj related The adj related has 2 senses (first 2 from tagged texts) 1. (20) related, related to -- (being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces") 2. (4) related -- (connected by kinship, common origin, or marriage) --- WordNet end ---