ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for related out of >500 occurrences
273413 occurrences (No.92 in the rank) during 5 years in the PubMed. [no cache]
500 found
270) The time-related and dose-response effects of ethanol on rectal temperature, handling-induced convulsions (HIC) and blood ethanol concentrations were evaluated in CB2 KO and wild-type (WT) mice.
* Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol.
- This study examines the role of the cannabinoid CB2 receptor (CB2 r) on the vulnerability to ethanol consumption. The time-related and dose-response effects of ethanol on rectal temperature, handling-induced convulsions (HIC) and blood ethanol concentrations were evaluated in CB2 KO and wild-type (WT) mice. The reinforcing properties of ethanol were evaluated in conditioned place preference (CPP), preference and voluntary ethanol consumption and oral ethanol self-administration. Water-maintained behavior schedule was performed to evaluate the degree of motivation induced by a natural stimulus. Preference for non-alcohol tastants assay was performed to evaluate the differences in taste sensitivity. Tyrosine hydroxylase (TH) and μ-opioid receptor gene expressions were also measured in the ventral tegmental area and nucleus accumbens (NAcc), respectively. CB2 KO mice presented increased HIC score, ethanol-CPP, voluntary ethanol consumption and preference, acquisition of ethanol self-administration, and increased motivation to drink ethanol compared with WT mice. No differences were found between genotypes in the water-maintained behavior schedule or preference for non-alcohol tastants. Naïve CB2 KO mice presented increased μ-opioid receptor gene expression in NAcc. Acute ethanol administration (1-2 g/kg) increased TH and μ-opioid receptor gene expressions in CB2 KO mice, whereas the lower dose of ethanol decreased TH gene expression in WT mice. These results suggest that deletion of the CB2 r gene increased preference for and vulnerability to ethanol consumption, at least in part, by increased ethanol-induced sensitivity of the TH and μ-opioid receptor gene expressions in mesolimbic neurons. Future studies will determine the role of CB2 r as a target for the treatment of problems related with alcohol consumption.
=>1.関係のある, 関連した, 2.同族の, 親類関係にある
Overview of verb relate
The verb relate has 5 senses (first 5 from tagged texts)
1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal
connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I
cannot relate these events at all")
2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be
relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your
earlier comments")
3. (7) relate -- (give an account of; "The witness related the events")
4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?")
5. (2) relate -- (have or establish a relationship to; "She relates well to her peers")
Overview of adj related
The adj related has 2 senses (first 2 from tagged texts)
1. (20) related, related to -- (being connected either logically or causally or by shared
characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle
formation is the...ability of detergent actives to congregate at oil-water interfaces")
2. (4) related -- (connected by kinship, common origin, or marriage)
--- WordNet end ---