ELIZA

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273413 occurrences (No.92 in the rank) during 5 years in the PubMed. [no cache] 500 found

240) In contrast, the expression levels of AHR and related genes (cyp1a1 and cyp1b1) were not markedly affected.

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PMID:23804495 DOI:10.1002/tox.21885

2015 Environmental toxicology

* The combined effects of DEHP and PCBs on phospholipase in the livers of mice.

- Di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) are two widely distributed pollutants that are of great concern due to their adverse health effects. However, few studies have investigated the combined effects of DEHP and PCBs. In this study, adult mice were continuously exposed to mixtures of DEHP (15 mg/kg bodyweight/day) and Aroclor 1254 (7.5 mg/kg bodyweight/day) for 12 days to investigate the combined effects of these compounds. The results showed that the ratio of the liver weight to the body weight was higher in the treated group than that in the control group. The effects of combined exposure on three important receptors, the proliferator-activated receptor (PPAR), estrogen receptor (ER), and aryl hydrocarbon receptor (AHR), were investigated. The mRNA level of PPARγ was significantly up-regulated after exposure. The expression level of ERα was decreased in the male treated group. In contrast, the expression levels of AHR and related genes (cyp1a1 and cyp1b1) were not markedly affected. The expression level of phospholipase A (PLA) was significantly down-regulated at both the mRNA and protein levels in male mice after combined treatment. In all, our study demonstrated the combined effects of DEHP and PCBs on the expression levels of key receptors in mice. The combined exposure led to a decrease in phospholipase in male mice.

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(1)212 to	(11)4 and	(21)3 changes	(31)2 characteristics
(2)11 quality	(12)4 cognitions	(22)3 death	(32)2 genes,
(3)7 factors	(13)4 deaths	(23)3 disease	(33)2 head
(4)6 complications	(14)4 events	(24)3 functional	(34)2 hospital
(5)6 genes	(15)4 issues	(25)3 stress	(35)2 increases
(6)5 health	(16)4 macular	(26)3 symptoms	(36)2 parameters
(7)5 information	(17)4 osteonecrosis	(27)2 Anxiety	(37)2 proteins
(8)5 injuries	(18)4 with	(28)2 Cognitions	(38)2 psychosocial
(9)5 potentials	(19)3 activity	(29)2 barriers	(39)2 species
(10)4 activities	(20)3 cases	(30)2 brain

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--- WordNet output for related --- =>1.関係のある, 関連した, 2.同族の, 親類関係にある Overview of verb relate The verb relate has 5 senses (first 5 from tagged texts) 1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your earlier comments") 3. (7) relate -- (give an account of; "The witness related the events") 4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?") 5. (2) relate -- (have or establish a relationship to; "She relates well to her peers") Overview of adj related The adj related has 2 senses (first 2 from tagged texts) 1. (20) related, related to -- (being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces") 2. (4) related -- (connected by kinship, common origin, or marriage) --- WordNet end ---