ELIZA

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273413 occurrences (No.92 in the rank) during 5 years in the PubMed. [no cache] 500 found

228) We investigated the effect of HA on the regulation of endothelial nitric oxide (NO) synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) to evaluate the involvement of eNOS and related factors in peripheral vascular impairment with HA exposure.

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PMID:23836447 DOI:10.1002/tox.21888

2015 Environmental toxicology

* Humic acid induces the endothelial nitric oxide synthase phosphorylation at Ser1177 and Thr495 Via Hsp90α and Hsp90β upregulation in human umbilical vein endothelial cells.

- Humic acid (HA) has been implicated as a contributory factor for blackfoot disease, which is an endemic peripheral vascular disease. We investigated the effect of HA on the regulation of endothelial nitric oxide (NO) synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) to evaluate the involvement of eNOS and related factors in peripheral vascular impairment with HA exposure. Treatment of HUVECs with HA induced upregulation of eNOS. This result coincides with those of previous studies. Furthermore this is the first study to report that HA induces upregulation of heat shock protein (Hsp)90α, Hsp90β, eNOS phosphorylation at Ser1177, and eNOS phosphorylation at Thr495, as compared to that in the control. In contrast, treatment with BAPTA, an intracellular Ca(2+) chelator, inhibited upregulation of these proteins induced by HA. This study demonstrates that HA treatment leads to increases in both Hsp90α and Hsp90β proteins and indicates that Hsp90α leads to eNOS phosphorylation at Ser1177 and that Hsp90β leads to eNOS phosphorylation at Thr495, respectively. Upregulation of eNOS, Hsp90α, and Hsp90β in HUVECs is regulated by intracellular Ca(2+) accumulation induced by HA. These results suggest that upregulation of eNOS phosphorylation at Ser1177 and eNOS phosphorylation at Thr495 produce NO and superoxide anions, respectively, resulting in generation of peroxynitrite, which causes impairment of vascular endothelial cells.

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(1)212 to	(11)4 and	(21)3 changes	(31)2 characteristics
(2)11 quality	(12)4 cognitions	(22)3 death	(32)2 genes,
(3)7 factors	(13)4 deaths	(23)3 disease	(33)2 head
(4)6 complications	(14)4 events	(24)3 functional	(34)2 hospital
(5)6 genes	(15)4 issues	(25)3 stress	(35)2 increases
(6)5 health	(16)4 macular	(26)3 symptoms	(36)2 parameters
(7)5 information	(17)4 osteonecrosis	(27)2 Anxiety	(37)2 proteins
(8)5 injuries	(18)4 with	(28)2 Cognitions	(38)2 psychosocial
(9)5 potentials	(19)3 activity	(29)2 barriers	(39)2 species
(10)4 activities	(20)3 cases	(30)2 brain

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--- WordNet output for related --- =>1.関係のある, 関連した, 2.同族の, 親類関係にある Overview of verb relate The verb relate has 5 senses (first 5 from tagged texts) 1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your earlier comments") 3. (7) relate -- (give an account of; "The witness related the events") 4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?") 5. (2) relate -- (have or establish a relationship to; "She relates well to her peers") Overview of adj related The adj related has 2 senses (first 2 from tagged texts) 1. (20) related, related to -- (being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces") 2. (4) related -- (connected by kinship, common origin, or marriage) --- WordNet end ---