* UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.
- UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is the key enzyme of sialic acid biosynthesis in vertebrates. It catalyzes the first two steps of the cytosolic formation of CMP-N-acetylneuraminic acid from UDP-N-acetylglucosamine. In this review we give an overview of structure, biochemistry, and genetics of the bifunctional enzyme and its complex regulation. Furthermore, we will focus on diseases related to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.
=>1.関係のある, 関連した, 2.同族の, 親類関係にある
Overview of verb relate
The verb relate has 5 senses (first 5 from tagged texts)
1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal
connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I
cannot relate these events at all")
2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be
relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your
earlier comments")
3. (7) relate -- (give an account of; "The witness related the events")
4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?")
5. (2) relate -- (have or establish a relationship to; "She relates well to her peers")
Overview of adj related
The adj related has 2 senses (first 2 from tagged texts)
1. (20) related, related to -- (being connected either logically or causally or by shared
characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle
formation is the...ability of detergent actives to congregate at oil-water interfaces")
2. (4) related -- (connected by kinship, common origin, or marriage)
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