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10) Seven important parameters related to HIV-1 in-host dynamics were estimated, most of them treated as global parameters across the group of patients.
2015 Mathematical medicine and biology : a journal of the IMA
* Bayesian estimation of HIV-1 dynamics in vivo.
- Statistical analysis of viral dynamics in HIV-1 infected patients undergoing structured treatment interruptions were performed using a novel model that accounts for treatment efficiency as well as total CD8+ T cell counts. A brief review of parameter estimates obtained in other studies is given, pointing to a considerable variation in the estimated values. A Bayesian approach to parameter estimation was used with longitudinal measurements of CD4+ and CD8+ T cell counts and HIV RNA. We describe an estimation procedure which uses spline approximations of CD8+ T cells dynamics. This approach reduces the number of parameters that must be estimated and is especially helpful when the CD8+ T cells growth function has a delayed dependence on the past. Seven important parameters related to HIV-1 in-host dynamics were estimated, most of them treated as global parameters across the group of patients. The estimated values were mainly in keeping with the estimates obtained in other reports, but our paper also introduces the estimates of some new parameters which supplement the current knowledge. The method was also tested on a simulated data set.
=>1.関係のある, 関連した, 2.同族の, 親類関係にある
Overview of verb relate
The verb relate has 5 senses (first 5 from tagged texts)
1. (15) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal
connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I
cannot relate these events at all")
2. (9) refer, pertain, relate, concern, come to, bear on, touch, touch on, have-to doe with -- (be
relevant to; "There were lots of questions referring to her talk"; "My remark pertained to your
earlier comments")
3. (7) relate -- (give an account of; "The witness related the events")
4. (4) relate, interrelate -- (be in a relationship with; "How are these two observations related?")
5. (2) relate -- (have or establish a relationship to; "She relates well to her peers")
Overview of adj related
The adj related has 2 senses (first 2 from tagged texts)
1. (20) related, related to -- (being connected either logically or causally or by shared
characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle
formation is the...ability of detergent actives to congregate at oil-water interfaces")
2. (4) related -- (connected by kinship, common origin, or marriage)
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