* Comparison of film-coated retarded release pellets manufactured by layering technique or by bed rotor pelletization.
- In order to investigate the influence of coatings for controlled active pharmaceutical ingredient (API) release, two types of pellets were used. Microcrystalline pellets were coated with a model API using the Wurster fluidized bed technique in laboratory scale (layered Cellets). Another type of pellets consisting of microcrystalline cellulose and model API was manufactured by fluidized bed rotor pelletization (matrix pellets (MP)). Both kinds of pellets were coated in a Wurster fluidized bed process with a polymer mixture of ethylcellulose to achieve retarded API release. With layered Cellets and an increased thickness of the ethylcellulose layer, the lag-time was increased and the release rate was decreased. In the case of MP, retardation was less pronounced probable due to inhomogeneous polymer film formation as a result of the porous particle surface. To reduce the surface roughness, the MP were coated with polyvinylpyrrolidone (PVP) as an intermediate smoothing layer, in a first trial step by step. In a second trial, pelletization and the coating steps were performed in an uninterrupted process. Intermediate PVP coating improved the ethylcellulose film formation and led to a more pronounced retardation of API release. The uninterrupted process of matrix pellet manufacturing and coating results in a product with only low retarded release.
=>価格を評定する, 割合, 率, 歩合, 料金, 値段, 相場, 速度, 度合, 人を〜を思う, みなす, 価値がある,
人を〜とみなす, 科金, 評価する
Overview of noun rate
The noun rate has 4 senses (first 3 from tagged texts)
1. (68) rate -- (a magnitude or frequency relative to a time unit; "they traveled at a rate of 55
miles per hour"; "the rate of change was faster than expected")
2. (39) rate, charge per unit -- (amount of a charge or payment relative to some basis; "a 10-minute
phone call at that rate would cost $5")
3. (1) pace, rate -- (the relative speed of progress or change; "he lived at a fast pace"; "he works
at a great rate"; "the pace of events accelerated")
4. rate -- (a quantity or amount or measure considered as a proportion of another quantity or amount
or measure; "the literacy rate"; "the retention rate"; "the dropout rate")
Overview of verb rate
The verb rate has 3 senses (first 3 from tagged texts)
1. (9) rate, rank, range, order, grade, place -- (assign a rank or rating to; "how would you rank
these students?"; "The restaurant is rated highly in the food guide")
2. (2) rate -- (be worthy of or have a certain rating; "This bond rates highly")
3. (1) rate, value -- (estimate the value of; "How would you rate his chances to become President?";
"Gold was rated highly among the Romans")
--- WordNet end ---